Howell-Jolly body-like inclusions

Howell-Jolly body-like inclusions (HJBLi) are a hematopathological finding of an inclusion arising from detached DNA nuclear fragment in white blood cells caused by dysplastic granulopoiesis.[1] The inclusion is aptly named for its similar appearance of the Howell–Jolly body in erythrocytes.[2] The term was coined in 1989.[2]

They are most often observed in neutrophils, but can also appear in monocytes, lymphocytes, eosinophils.[2]

They may appear in patients on immunosuppression and antiviral therapies with nucleoside analogs, anticancer chemotherapeutic agents, active COVID-19 infections, HIV/AIDS, and myelodysplastic syndrome.[3][1]

References

  1. ^ a b "Morphology of Blood Cells". Blood Cells: A Practical Guide. 9 June 2006. pp. 61–174. doi:10.1002/9780470987551.ch3. ISBN 978-1-4051-4265-6.
  2. ^ a b c Oehadian, A; Huang, I; Kartikasari, A; Alisjahbana, B; Prihatni, D (2023). "Howell-Jolly Body-Like Inclusions in Coronavirus Disease 2019 (COVID-19): Possible Novel Findings". Journal of Blood Medicine. 14: 233–238. doi:10.2147/JBM.S399596. PMC 10066893. PMID 37016662.
  3. ^ Tong, YT; Nguyen, ND; Wahed, A (January 2019). "Howell-Jolly Body-Like Inclusions in Neutrophils of Patients With Myelodysplastic Syndrome: A Novel Correlation". Archives of Pathology & Laboratory Medicine. 143 (1): 112–114. doi:10.5858/arpa.2017-0328-OA. PMID 30059259.