To'oTo'o became a starting linebacker at Tennessee early in his true freshman season and was named to the Southeastern Conference (SEC) All-Freshman team after finishing second on the team with 72 tackles.[6] He led the Volunteers with 76 tackles, 10 of which were for a loss, in his sophomore season.[7] In his first game of the 2020 season, he had a pick-six against South Carolina.[8] After the season, To'oTo'o announced that he would be entering the transfer portal.[9]
Alabama
To'oTo'o transferred to the University of Alabama in 2021.[10][11] He repeated as a second team All-SEC selection after leading the Crimson Tide with 113 tackles and had 8.5 for loss and four sacks in his first season with the team.[12] To'oTo'o was named first team All-SEC as a senior after making 94 tackles with eight tackles for loss and 2.5 sacks.[13]
In his second season with Alabama, To'oTo'o had 94 total tackles and 2.5 sacks.[14]
To'oTo'o was selected by the Houston Texans in the fifth round, 167th overall, of the 2023 NFL draft.[17] As a rookie, To'oTo'o appeared in 14 games and started six. He recorded 61 total tackles (35 solo), two passes defended, and one forced fumble.[18]