HNRPH1

HNRNPH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LXU
Identifiers
Aliases	HNRNPH1, HNRPH, HNRPH1, hnRNPH, heterogeneous nuclear ribonucleoprotein H1 (H), heterogeneous nuclear ribonucleoprotein H1
External IDs	OMIM: 601035; MGI: 1891925; HomoloGene: 31318; GeneCards: HNRNPH1; OMA:HNRNPH1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.3 Start 179,614,178 bp[1] End 179,634,784 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 50,376,990 bp[2] End 50,386,528 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right uterine tube left ovary right ovary Achilles tendon body of pancreas right lung ganglionic eminence ventricular zone Top expressed in tail of embryo superior cervical ganglion hand abdominal wall mandibular prominence maxillary prominence genital tubercle primitive streak Gonadal ridge dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding protein binding RNA binding poly(U) RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex membrane nucleoplasm cytosol nucleus Biological process mRNA splicing, via spliceosome regulation of RNA splicing mRNA processing RNA processing RNA splicing fibroblast growth factor receptor signaling pathway RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3187 59013 Ensembl ENSG00000169045 ENSMUSG00000007850 UniProt P31943 O35737 RefSeq (mRNA) NM_001257293 NM_005520 NM_001363572 NM_021510 NM_001347487 RefSeq (protein) NP_001244222 NP_005511 NP_001350501 NP_001351154 NP_001351155 NP_001351156 NP_001351157 NP_001351158 NP_001351159 NP_001351160 NP_001351161 NP_001351162 NP_001351163 NP_001351164 NP_001351165 NP_001351166 NP_001351167 NP_001351168 NP_001351169 NP_001351170 NP_001351171 NP_001351172 NP_001351173 NP_001351174 NP_001351175 NP_001351176 NP_001351177 NP_001351179 NP_001351180 NP_001351181 NP_001351182 NP_001351183 NP_001351184 NP_001334416 NP_067485 NP_001349451 NP_001349452 NP_001349453 NP_001349454 NP_001349455 NP_001349456 NP_001349457 NP_001349458 NP_001349459 NP_001349461 NP_001349462 NP_001349463 Location (UCSC) Chr 5: 179.61 – 179.63 Mb Chr 11: 50.38 – 50.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein H is a protein[5] that in humans is encoded by the HNRNPH1 gene.[6][7]

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties; The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs, making it very similar to the family member HNRPF in that regard. This gene is thought to be potentially involved in hereditary lymphedema type I phenotype.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000169045 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000007850 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Penumutchu S, Chiu LY, Meagher JL, Hansen AL, Stuckey JA, Tolbert BS (2018-08-18). "Differential Conformational Dynamics Encoded by the Inter-qRRM linker of hnRNP H". Journal of the American Chemical Society. 140 (37): 11661–11673. doi:10.1021/jacs.8b05366. ISSN 0002-7863. PMC 6648666. PMID 30122033.
6. Honore B, Rasmussen HH, Vorum H, Dejgaard K, Liu X, Gromov P, Madsen P, Gesser B, Tommerup N, Celis JE (Jan 1996). "Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes". J Biol Chem. 270 (48): 28780–9. doi:10.1074/jbc.270.48.28780. PMID 7499401.
7. "Entrez Gene: HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H)".

Further reading

• Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis. 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. S2CID 41855774.
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Matunis MJ, Xing J, Dreyfuss G (1994). "The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization". Nucleic Acids Res. 22 (6): 1059–67. doi:10.1093/nar/22.6.1059. PMC 307930. PMID 7512260.
• Gamberi C, Izaurralde E, Beisel C, Mattaj IW (1997). "Interaction between the human nuclear cap-binding protein complex and hnRNP F." Mol. Cell. Biol. 17 (5): 2587–97. doi:10.1128/MCB.17.5.2587. PMC 232108. PMID 9111328.
• Chou MY, Rooke N, Turck CW, Black DL (1999). "hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells". Mol. Cell. Biol. 19 (1): 69–77. doi:10.1128/MCB.19.1.69. PMC 83866. PMID 9858532.
• Evans AL, Brice G, Sotirova V, et al. (1999). "Mapping of primary congenital lymphedema to the 5q35.3 region". Am. J. Hum. Genet. 64 (2): 547–55. doi:10.1086/302248. PMC 1377764. PMID 9973292.
• Honoré B, Vorum H, Baandrup U (1999). "hnRNPs H, H' and F behave differently with respect to posttranslational cleavage and subcellular localization". FEBS Lett. 456 (2): 274–80. doi:10.1016/S0014-5793(99)00911-4. PMID 10456323. S2CID 7617501.
• Markovtsov V, Nikolic JM, Goldman JA, et al. (2000). "Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein". Mol. Cell. Biol. 20 (20): 7463–79. doi:10.1128/MCB.20.20.7463-7479.2000. PMC 86300. PMID 11003644.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–37. doi:10.1523/JNEUROSCI.22-20-08827.2002. PMC 6757688. PMID 12388589.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Honoré B, Baandrup U, Vorum H (2004). "Heterogeneous nuclear ribonucleoproteins F and H/H' show differential expression in normal and selected cancer tissues". Exp. Cell Res. 294 (1): 199–209. doi:10.1016/j.yexcr.2003.11.011. PMID 14980514.
• Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. CiteSeerX 10.1.1.323.5263. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888.