Newsome recorded 71 tackles and one interception over three years at Northwestern.[3] He started 18 games and led the Wildcats to two Big Ten title games.[4][5] As a junior in 2020, he was named an All-American by The Athletic.[6] After that season, he entered the 2021 NFL draft.[7]
On April 29, 2021, Newsome was selected by the Cleveland Browns in the first round with the 26th overall pick in the 2021 NFL Draft.[11] Newsome's pick marked the first time Northwestern has had two first-round picks in the NFL draft after Rashawn Slater was taken 13th overall. He was the fourth cornerback taken in the draft.[12] On July 24, 2021, Newsome signed his four-year rookie contract with Cleveland, worth $12.75 million.[13] He started all 12 games he appeared in as a rookie. He had 37 total tackles and nine passes defensed.[14] He was named to the PFWA All-Rookie Team.[15] In the 2022 season, he started all 15 games he appeared in. He had .5 sacks, 42 total tackles, and six passes defensed.[16]
In Week 10 of the 2023 season, Newsome recorded his first interception off of Lamar Jackson and returned it for a touchdown as the Browns would go on to win 33-31.[17]
On April 30, 2024, the Browns picked up the fifth-year option on Newsome's contract.[18]