Glypican 6

GPC6
Identifiers
Aliases	GPC6, OMIMD1, Glypican 6
External IDs	OMIM: 604404; MGI: 1346322; HomoloGene: 55922; GeneCards: GPC6; OMA:GPC6 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q31.3-q32.1 Start 93,226,807 bp[1] End 94,408,020 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E4 Start 117,162,727 bp[2] End 118,213,956 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue tibia vena cava superficial temporal artery saphenous vein seminal vesicula pancreatic epithelial cell spinal ganglia synovial membrane caput epididymis Top expressed in ascending aorta aortic valve external carotid artery internal carotid artery sciatic nerve genital tubercle maxillary prominence mandibular prominence tail of embryo human fetus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparan sulfate proteoglycan binding coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway protein binding Cellular component Golgi lumen nucleus integral component of plasma membrane extracellular region anchored component of membrane lysosomal lumen membrane plasma membrane extracellular space anchored component of plasma membrane collagen-containing extracellular matrix glutamatergic synapse cell surface synapse Biological process glycosaminoglycan metabolic process retinoid metabolic process cell migration glycosaminoglycan biosynthetic process glycosaminoglycan catabolic process Wnt signaling pathway, planar cell polarity pathway regulation of signal transduction regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10082 23888 Ensembl ENSG00000183098 ENSMUSG00000058571 UniProt Q9Y625 Q9R087 RefSeq (mRNA) NM_005708 NM_001079844 NM_011821 RefSeq (protein) NP_005699 NP_001073313 NP_035951 Location (UCSC) Chr 13: 93.23 – 94.41 Mb Chr 14: 117.16 – 118.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glypican-6 is a protein that in humans is encoded by the GPC6 gene.[5][6]

The glypicans comprise a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans. The glypicans have been implicated in the control of cell growth and division. Glypican 6 is a putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases.[6]

See also

• Glypican

References

1. GRCh38: Ensembl release 89: ENSG00000183098 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058571 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Paine-Saunders S, Viviano BL, Saunders S (Aug 1999). "GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13". Genomics. 57 (3): 455–8. doi:10.1006/geno.1999.5793. PMID 10329016.
6. "Entrez Gene: GPC6 glypican 6".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Veugelers M, De Cat B, Ceulemans H, et al. (1999). "Glypican-6, a new member of the glypican family of cell surface heparan sulfate proteoglycans". J. Biol. Chem. 274 (38): 26968–77. doi:10.1074/jbc.274.38.26968. PMID 10480909.
• Watanabe K, Yamada H, Yamaguchi Y (1995). "K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney". J. Cell Biol. 130 (5): 1207–18. doi:10.1083/jcb.130.5.1207. PMC 2120559. PMID 7657705.

External links

• GPC6 human gene location in the UCSC Genome Browser.
• GPC6 human gene details in the UCSC Genome Browser.