In 2006 he was elected to the Italian Senate with Forza Italia.[3] While still taking part in Forza Italia's activities, he joined the parliamentary group "Democrazia Cristiana per le Autonomie" to allow them to reach the minimum required quorum for group constitution. As a legislator he rejected a proposal for the diminishing of members of parliament's salaries and benefits.[4]
Stracquadanio also worked as a journalist with the right-wing newspaper Libero, for which he edited some political pamphlets.
In 2009-2010, Stracquadanio was criticized for many controversial statements, including:
the delegitimisation of dissent in Berlusconi's party, the opposition to the explicit choice of MPs by electors, the support to ad personam laws favouring Silvio Berlusconi[6]
insults towards a left-wing journalist during a press conference[7][8]
legitimizing prostitution to gain access to public posts, and stating that if a female MP were discovered to have been selected in return for sexual favours, there would be no reason for her to resign, or even to feel embarrassed; he stated his position after Angela Napoli (MP of the same party) had remarked that she could not exclude the possibility that some women MPs and senators had been selected in this manner.[10][11]
In July 2012 he left Berlusconi's party and in December of the same year joined the political project built by Mario Monti.[12] Stracquadanio died of lung cancer on January 31, 2014 at the age of 54.[12]