As a fourth-year student, Omenn studied prenatal diagnosis of inherited conditions. He discovered what is now known as Omenn syndrome, a genetic disorder characterized by the loss of T-cell function. It is generally fatal in infancy, but some cases have responded to treatment.[12][2][13]
In 1971 Omenn joined the faculty of medical genetics at the University of Washington.[10][8]
Omenn was appointed as a White House Fellow in 1973-1974, under Presidents Richard Nixon and Gerald Ford. He was one of two staff on Nixon's Project Independence, looking for ways to lessen America's dependence on imported oil. He was also part of a diplomatic mission to convince France not to share nuclear information with Pakistan.[14] Omenn worked with the Atomic Energy Commission on international nuclear policy.[15]
Omenn founded the Robert Wood Johnson Clinical Scholars Program at the University of Washington in 1975.[10] He was a Howard Hughes Medical Institute investigator for 1976-1977.[17]
He was promoted to a full professorship in medicine in 1979.[10]
While at UW, Omenn began working with the Fred Hutchinson Cancer Research Center in Seattle, to conduct clinical trials in cancer prevention. He served as principal investigator of the beta-Carotene and Retinol Efficacy Trial (CARET) seeking preventive agents against lung cancer and heart disease.[18][19][20]
In 1982, Omenn became Chair of the Department of Environmental & Occupational Health Sciences (DEOHS) and then Dean of the School of Public Health at the University of Washington, serving from 1982-1997. He continues to be an affiliate professor of the university.[22]
In 1982, Omenn and Elaine Faustman at UW introduced a multi-disciplinary course on Risk Assessment and Risk Management.[10] Omenn's work on risk emphasizes science-based risk analysis and the importance of assessing health and ecological risks, communicating information, and reducing risks to health and the environment.[23]
From 1982-1988, Omen chaired the National Research Council's Committee on Science, Engineering and Public Policy.[24]
From 1990 to 1992, he served on the National Commission on the Environment, resulting in publication of "Choosing a Sustainable Future: The Report of the National Commission on the Environment" (1993).[25]
From 1994-1997, Omenn chaired the Presidential/Congressional Commission on Risk Assessment and Risk Management ("Omenn Commission").[24][8] The commission was mandated by the Clean Air Act Amendments of 1990, and disbanded as of August 31, 1997.[26][27]
We are stretching beyond the limits of science to discuss risk. So it is not surprising that scientists disagree on risk estimates or on what should be done, if anything, to reduce those risks. Nevertheless, the public finds such disagreement disconcerting, and the cartoonists mock us!... We need to explain better what is known and what is speculated.– Gilbert Omenn, 1996[23]
In 1997 Omenn moved to the University of Michigan.[8]
From 1997 to 2002 he served as Executive Vice President for Medical Affairs and as Chief Executive Officer of the University of Michigan Health System.[8][15]
In 2015 he was named the Harold T. Shapiro Distinguished University Professor of Medicine.[28]
Omenn was a founder of the international Human Proteome Organization (HUPO) in 2001, a member of the Council of HUPO's pilot Plasma Proteome Project from 2002 through 2010, and chair of the Human Proteome Project from 2010 through 2018.[29][30][31]
^Omenn, Gilbert S. (19 August 1965). "Familial Reticuloendotheliosis with Eosinophilia". New England Journal of Medicine. 273 (8): 427–432. doi:10.1056/NEJM196508192730806. PMID14328107.
