Gia Voeltz is an American cell biologist. She is a professor of Molecular, Cellular and
Developmental Biology at the University of Colorado Boulder and a Howard Hughes Medical Institute Investigator. She is known for her research identifying the factors and unraveling the
mechanisms that determine the structure and dynamics of the largest organelle in the cell: the
endoplasmic reticulum.
[1][2]
Her lab has produced paradigm shifting studies on
organelle membrane contact sites that have revealed that most cytoplasmic organelles are not isolated entities but are instead physically tethered to an interconnected ER membrane network.
[3][4][5]
Her research has revealed the fundamental nature of these ER contact sites in regulating the
biogenesis of other organelles at positions where they are tethered and closely opposed.
[6][7][8][9]
Early life and education
Gia Voeltz grew up in several different states including Indiana, Hawaii, Minnesota and Upstate New York, where she graduated from Chenango Forks High School. She attended university at the
University of California Santa Cruz where she majored in Biochemistry and Molecular Biology.
She performed her senior thesis work in the lab of Manny Ares
[10]
on pre-spliceosome assembly in yeast.
[11] This experience in the Ares lab at UC Santa Cruz inspired her to become a
scientist. Her early undergraduate research studying RNA processing led her to pursue a PhD
thesis in the Department of Molecular Biophysics and Biochemistry at Yale University in the lab
of Joan A. Steitz, a leading figure in RNA biology. Her PhD research investigated how mRNA
stability was regulated during different stages of early development using Xenopus eggs and
extract as a model system.
[12][13]
Gia Voeltz was trained as an RNAbiologist but made a major switch in scientific sub-fields when
she moved to Tom Rapoport’s lab as a postdoc to study how organelles get their shape. As a
postdoc, she set out to identify how membrane proteins generate the elaborate shape of the ER.
To do this, she used biochemical fractionation of a Xenopus egg in vitroassay for ER network formation.[14]
Her postdoctoral studies identified the Reticulon family of ER membrane
proteins and demonstrated their conserved role in generating the structure of the tubular ER
network.[2] The hairpin "wedge" mechanism proposed was that Reticulon has two short hairpin transmembrane domains that occupy more area in the outer leaflet to generate the high membrane curvature found in tubules.[2]
Gia Voeltz moved to University of Colorado Boulder in 2006[15] to start her own lab. Her
lab leveraged spinning disk confocal microscopy to visualize the reticulon-generated dynamic tubular ER network in live cells at high resolution.[3] This led to the observation that ER tubule dynamics often occurred at positions where the ER tubules were tightly tethered to other dynamic organelles like endosomes and mitochondria.[3][4]
Multi-color live cell fluorescence imaging complemented by high resolution electron microscopy and tomography revealed that the vast majority of endosomes and mitochondria are
tethered to the ER at contact sites. In a hallmark paper published in 2011, Voeltz lab, in a collaboration with Jodi Nunnari’s lab, showed that ER tubules wrap around mitochondria to define the position where mitochondria constrict and divide in animal and yeast cells.[6]
