GFI1B

GFI1B
Identifiers
Aliases	GFI1B, BDPLT17, ZNF163B, growth factor independent 1B transcriptional repressor
External IDs	OMIM: 604383; MGI: 1276578; HomoloGene: 31223; GeneCards: GFI1B; OMA:GFI1B - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.13 Start 132,944,000 bp[1] End 132,991,687 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 28,499,462 bp[2] End 28,511,994 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm trabecular bone monocyte bone marrow blood left testis right testis granulocyte testicle bone marrow cells Top expressed in fetal liver hematopoietic progenitor cell embryo tibiofemoral joint yolk sac spleen blood tail of embryo bone marrow zygote embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear matrix nucleus transcription regulator complex Biological process multicellular organism development cell population proliferation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated chromatin organization negative regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8328 14582 Ensembl ENSG00000165702 ENSMUSG00000026815 UniProt Q5VTD9 O70237 RefSeq (mRNA) NM_001135031 NM_004188 NM_001371908 NM_001377304 NM_001377305 NM_001160406 NM_008114 RefSeq (protein) NP_001128503 NP_004179 NP_001358837 NP_001364233 NP_001364234 NP_001153878 NP_032140 Location (UCSC) Chr 9: 132.94 – 132.99 Mb Chr 2: 28.5 – 28.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000165702 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026815 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rodel B, Wagner T, Zornig M, Niessing J, Moroy T (Feb 1999). "The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases". Genomics. 54 (3): 580–2. doi:10.1006/geno.1998.5601. PMID 9878267.
6. "Entrez Gene: GFI1B growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)".

Further reading

• Tong B, Grimes HL, Yang TY, et al. (1998). "The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation". Mol. Cell. Biol. 18 (5): 2462–73. doi:10.1128/mcb.18.5.2462. PMC 110626. PMID 9566867.
• Osawa M, Yamaguchi T, Nakamura Y, et al. (2002). "Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis". Blood. 100 (8): 2769–77. doi:10.1182/blood-2002-01-0182. PMID 12351384.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Huang DY, Kuo YY, Lai JS, et al. (2004). "GATA-1 and NF-Y cooperate to mediate erythroid-specific transcription of Gfi-1B gene". Nucleic Acids Res. 32 (13): 3935–46. doi:10.1093/nar/gkh719. PMC 506805. PMID 15280509.
• Garçon L, Lacout C, Svinartchouk F, et al. (2005). "Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells". Blood. 105 (4): 1448–55. doi:10.1182/blood-2003-11-4068. PMID 15507521.
• Huang DY, Kuo YY, Chang ZF (2005). "GATA-1 mediates auto-regulation of Gfi-1B transcription in K562 cells". Nucleic Acids Res. 33 (16): 5331–42. doi:10.1093/nar/gki838. PMC 1226314. PMID 16177182.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Xu W, Kee BL (2007). "Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas". Blood. 109 (10): 4406–14. doi:10.1182/blood-2006-08-043331. PMID 17272506.
• Kuo YY, Chang ZF (2007). "GATA-1 and Gfi-1B interplay to regulate Bcl-xL transcription". Mol. Cell. Biol. 27 (12): 4261–72. doi:10.1128/MCB.02212-06. PMC 1900040. PMID 17420275.