Early in his career, he was a cleric in Viterbo.[1] In 1485, he became a canon of St. Lambert's Cathedral, Liège.[1] He was the pedagogus of Giuliano della Rovere, the future cardinal and future Pope Julius II; when della Rovere became a cardinal, he took Santori into his household.[1] He served as a datary from November 1503 to December 1505.[1] He was the dean of the Apostolic Camera in 1503.[1]
On 22 July 1504 he was elected Bishop of Cesena.[1] He subsequently occupied that see until his death.[1]