Family of enzymes
In molecular biology the FGGY carbohydrate kinase family is a family of evolutionarily related carbohydrate kinase enzymes . These enzymes include L-fuculokinase EC 2.7.1.51 (gene fucK); gluconokinase EC 2.7.1.12 (gene gntK); glycerol kinase EC 2.7.1.30 (gene glpK); xylulokinase EC 2.7.1.17 (gene xylB); D-ribulose kinase EC 2.7.1.47 (gene FGGY/YDR109c);[ 1] L-xylulose kinase EC 2.7.1.53 (gene lyxK). These enzymes are proteins of from 480 to 520 amino acid residues.
These enzymes consist of two domains . The N-terminal and C-terminal domains both adopt a ribonuclease H -like fold and are structurally related to each other.[ 1] [ 2] [ 3]
References
^ a b Singh C, Glaab E, Linster C (2016). "Molecular Identification of D-Ribulokinase in Budding Yeast and Mammals" . J. Biol. Chem . 292 (3): 1005–1028. doi :10.1074/jbc.M116.760744 PMC 5247636 PMID 27909055 . ^ Hurley JH, Faber HR, Worthylake D, Meadow ND, Roseman S, Pettigrew DW, Remington SJ (January 1993). "Structure of the regulatory complex of Escherichia coli IIIGlc with glycerol kinase". Science . 259 (5095): 673–7. Bibcode :1993Sci...259..673H . doi :10.1126/science.8430315 . PMID 8430315 . S2CID 20908371 . ^ Ormo M, Bystrom CE, Remington SJ (November 1998). "Crystal structure of a complex of Escherichia coli glycerol kinase and an allosteric effector fructose 1,6-bisphosphate". Biochemistry . 37 (47): 16565–72. doi :10.1021/bi981616s . PMID 9843423 .
