Erika Crouch

Erika Crouch is a professor of pathology and the Carol B. and Jerome T. Loeb Professor of Medical Education at Washington University in St. Louis.

Early life and education

Crouch received her B.S. from Washington State University in 1972.[1] Crouch earned her Ph.D. in 1978 and then her M.D. in 1979, both from the University of Washington. She was a postdoctoral fellow and then a resident in anatomic pathology at the University of Washington. She completed a fellowship in pulmonary pathology at the University of British Columbia as a Parker B. Francis Fellow.[2] In 1983 Crouch joined the Washington University in St. Louis faculty, and as of 2024 she is the Carol B. and Jerome T. Loeb Professor of Medical Education.[3]

Career and research

Crouch is known for her research in collectins, a carbohydrate binding protein that is involved in the immune system.[4] She identified CP4, a novel secreted collagenous protein,[5] and went on to determine its molecular structure.[6] Working with John Heuser, she examined a surfactant protein, SP-D,[7][8] and researched the interactions between SP-D and influenza A virus.[9] She has also used structure-function analysis via crystallographic analysis and site-directed mutagenesis.[10]

Publications

  • Crouch, E. (1990-10-01). "Pathobiology of pulmonary fibrosis". American Journal of Physiology. Lung Cellular and Molecular Physiology. 259 (4): L159 – L184. doi:10.1152/ajplung.1990.259.4.L159. ISSN 1040-0605.
  • Kuan, S F; Rust, K; Crouch, E (1992-07-01). "Interactions of surfactant protein D with bacterial lipopolysaccharides. Surfactant protein D is an Escherichia coli-binding protein in bronchoalveolar lavage". Journal of Clinical Investigation. 90 (1): 97–106. doi:10.1172/JCI115861. ISSN 0021-9738. PMC 443067. PMID 1634623.
  • Crouch, Erika; Hartshorn, Kevan; Ofek, Itzhak (2000). "Collectins and pulmonary innate immunity". Immunological Reviews. 173 (1): 52–65. doi:10.1034/j.1600-065X.2000.917311.x. ISSN 0105-2896.
  • Crouch, Erika; Wright, Jo Rae (2001). "Surfactant Proteins A and D and Pulmonary Host Defense". Annual Review of Physiology. 63 (1): 521–554. doi:10.1146/annurev.physiol.63.1.521. ISSN 0066-4278.

References

  1. ^ "Erika Crouch | Medical Scientist Training Program". Retrieved 2024-05-22.
  2. ^ "Erika Crouch and SP-D | Erika Crouch Lab". wupathlabs.wustl.edu. Retrieved 2023-02-28.
  3. ^ "Erika Crouch, MD, PhD | Pathology & Immunology | Washington University in St. Louis". pathology.wustl.edu. Retrieved 2023-02-28.
  4. ^ Crouch, Erika C. (1998-08-01). "Collectins and Pulmonary Host Defense". American Journal of Respiratory Cell and Molecular Biology. 19 (2): 177–201. doi:10.1165/ajrcmb.19.2.140. ISSN 1044-1549.
  5. ^ Persson, Anders; Rust, Kevin; Chang, Donald; Moxley, Michael; Longmore, William; Crouch, Edmound (1988-11-15). "CP4: a pneumocyte-derived collagenous surfactant-associated protein. Evidence for heterogeneity of collagenous surfactant proteins". Biochemistry. 27 (23): 8576–8584. doi:10.1021/bi00423a011. ISSN 0006-2960.
  6. ^ Crouch, E.; Persson, A.; Chang, D.; Heuser, J. (1994). "Molecular structure of pulmonary surfactant protein D (SP-D)". Journal of Biological Chemistry. 269 (25): 17311–17319. doi:10.1016/s0021-9258(17)32556-5. ISSN 0021-9258.
  7. ^ Crouch, Erika C. (1998-11-19). "Structure, biologic properties, and expression of surfactant protein D (SP-D)". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1408 (2): 278–289. doi:10.1016/S0925-4439(98)00073-8. ISSN 0925-4439.
  8. ^ Hanson, Phyllis I.; Stahl, Philip D. (2004). "From the neuromuscular junction to cellular architecture and beyond – commentary on 30 years of imaging by John E. Heuser". European Journal of Cell Biology. 83 (6): 229–242. doi:10.1078/0171-9335-00398. ISSN 0171-9335.
  9. ^ Hartshorn, K L; Crouch, E C; White, M R; Eggleton, P; Tauber, A I; Chang, D; Sastry, K (1994-07-01). "Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses". Journal of Clinical Investigation. 94 (1): 311–319. doi:10.1172/JCI117323. ISSN 0021-9738. PMC 296311. PMID 8040272.
  10. ^ Seaton, Barbara A.; Crouch, Erika C.; McCormack, Francis X.; Head, James F.; Hartshorn, Kevan L.; Mendelsohn, Richard (2010). "Review: Structural determinants of pattern recognition by lung collectins". Innate Immunity. 16 (3): 143–150. doi:10.1177/1753425910368716. ISSN 1753-4259.