Endonuclease/Exonuclease/phosphatase family

Endonuclease/Exonuclease/phosphatase family
Structure of the multifunctional DNA-repair enzyme exonuclease III.[1]
Identifiers
Symbol	Exo_endo_phos
Pfam	PF03372
InterPro	IPR005135
PROSITE	PDOC00598
SCOP2	1ako / SCOPe / SUPFAM
OPM superfamily	139
OPM protein	1zwx
CDD	cd08372
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Endonuclease/Exonuclease/phosphatase family is a structural domain found in the large family of proteins including magnesium dependent endonucleases and many phosphatases involved in intracellular signaling.[2]

Examples

• AP endonuclease proteins EC 4.2.99.18,
• DNase I proteins EC 3.1.21.1,
• Synaptojanin, an inositol-1,4,5-trisphosphate phosphatase EC 3.1.3.56
• Sphingomyelinase EC 3.1.4.12
• Nocturnin, an NADPH 2' phosphatase[3]

Subfamilies

• Inositol polyphosphate related phosphatase InterPro: IPR000300

Human proteins containing this domain

2'-PDE; 2-PDE; ANGEL1; ANGEL2; APEX1; APEX2; CCRN4L; CNOT6; CNOT6L; DNASE1; DNASE1L1; DNASE1L2; DNASE1L3; INPP5A; INPP5B; INPP5D; INPP5E; INPPL1; KIAA1706; OCRL; PIB5PA; SKIP; SMPD2; SMPD3; SYNJ1; SYNJ2; TTRAP; Nocturnin;

Notes

1. Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA (March 1995). "Structure and function of the multifunctional DNA-repair enzyme exonuclease III". Nature. 374 (6520): 381–6. doi:10.1038/374381a0. PMID 7885481. S2CID 4335526.
2. Dlaki M (2000). "Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases". Trends Biochem. Sci. 25 (6): 272–273. doi:10.1016/S0968-0004(00)01582-6. PMID 10838565.
3. Estrella MA, Du J, Chen L, Rath S, Prangley E, Chitrakar A, Aoki T, Schedl P, Rabinowitz J, Korennykh A (May 2019). "The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled)". Nature Communications. 10 (1): 2367. doi:10.1038/s41467-019-10125-z. PMC 6542800. PMID 31147539.
   • "Circadian clock and fat metabolism linked through newly discovered mechanism". ScienceDaily (Press release). May 30, 2019.

References

• Dlakić M (June 2000). "Functionally unrelated signalling proteins contain a fold similar to Mg^2+-dependent endonucleases". Trends Biochem. Sci. 25 (6): 272–3. doi:10.1016/S0968-0004(00)01582-6. PMID 10838565.
• Mol CD, Kuo CF, Thayer MM, Cunningham RP, Tainer JA (March 1995). "Structure and function of the multifunctional DNA-repair enzyme exonuclease III". Nature. 374 (6520): 381–6. doi:10.1038/374381a0. PMID 7885481. S2CID 4335526.
• Lahm A, Suck D (December 1991). "DNase I-induced DNA conformation. 2 A structure of a DNase I-octamer complex". J. Mol. Biol. 222 (3): 645–67. doi:10.1016/0022-2836(91)90502-W. PMID 1748997.