Mossel's research spans a number of topics across mathematics, statistics, economics, and computer science, including combinatorial statistics, discrete functional inequalities, isoperimetry, game theory, social choice, computational complexity, and computational evolutionary biology.
Mossel has worked on the reconstruction problem on trees. He connected it to Steel's conjecture in Phylogenetic reconstruction, partially in work with Constantinos Daskalakis and Sébastien Roch.[3][4] These result links the extremality of the Ising model on the Bethe lattice to a phase transition in the amount of data required for statistical inference on phylogenetic trees.
With Joe Neeman and Allan Sly he established the role of the reconstruction problem on trees for the problem of detection in block models.[5][6]
2019 Class of fellows of the American Mathematical Society "for contributions to probability, combinatorics, computing, and especially the interface between them".[10]
2020 Vannevar Bush Faculty Fellowship of the U.S. Department of Defense.[11]
2021 Fellow of the Association for Computing Machinery "for contributions to theoretical computer science and inference".[12]
2022 Special Sectional Lecture at International Congress of Mathematics 2022 titled "Combinatorial Statistics and the Sciences" (in sections 12 = probability, 13 = combinatorics, 14 = mathematics of computer science and 18 = stochastic and differential modeling).[13]
^Evolutionary trees and the Ising model on the Bethe lattice: a proof of Steel’s conjecture, Probability Theory and Related Fields, 2011, Volume 149, Issue 1–2, pp 149–189 doi:10.1007/s00440-009-0246-2
^Reconstruction and estimation in the planted partition model, Probability Theory and Related Fields, 2015, Volume 162, Issue 3, pp 431–461 doi:10.1007/s00440-014-0576-6
^A proof of the block model threshold conjecture, Combinatorica, 2018, Volume 38, Issue 3, pp 665-708 doi:10.1007/s00493-016-3238-8