He married Isabel Forster, the daughter of Thomas Forster of Tong, Shropshire.[2] Isabel was reported to be a family chambermaid in a letter to the Earl of Leicester which includes "My Lorde Stafford's son is basely married to his mother's chambermaid."[3]
Edward Stafford continued on with his father's patronage of the Lord Stafford's Company, a travelling group of players, who were active until at least 1617.[4]
Death and succession
Stafford had one son, Edward (1602 – 6 April 1621). This son married Ann Wilford, daughter of James Wilford, Newman Hall, Quendon, Essex, and had two children:
Henry Stafford, 5th Baron Stafford (24 September 1621 – 4 August 1637). Born after his father's death, he inherited the barony upon his grandfather the fourth baron's death in 1625.[3]