He married Mary Ann Briggs on 7 October 1856 at St Mary's Church, Moseley. Mary Ann was the daughter of Samuel and Elizabeth Briggs. There were three children: Elizabeth Henriette Holmes (1857 - 1944), Edward Briggs Holmes (1858 - 1920) and Gertrude Fanny Holmes (1861-1938).
There is a brass plaque in St Mary's Church, Selly Oak to the memory of Mary Ann Holmes aged 31 years, wife of Edward Holmes (Architect of this Church) who died 5 November 1861 and is buried in the Family Vault at St Mary's Church, Moseley.
Holmes married Mary Lavinia Hemming on 27 May 1863 in Alvechurch. They had a further 11 children.
He was for many years architect to the King’s Norton School Board, and to King’s Norton District Council. For this and for the Aston and Handsworth Boards he designed a number of school buildings.[1]
He contracted pneumonia just before Christmas 1909 and died at Wyndcliffe, School Road, Moseley on 30 December 1909[2] and his funeral was held in Moseley parish church on 3 January 1910. Mary Lavinia died in 1921.