In 2005, Du competed in the Hunan TV hosting competition Shining New Anchor. Winning the competition in 2006, Du, along with runner-up Wu Xin, joined the Happy Camp as a host, with existing members He Jiong, Xie Na, and Li Weijia, forming the Happy Family. The same year, Du hosted the education program Tong Xin Zhuang Di Qiu (Chinese: 童心撞地球) for the cartoon department of Hunan TV.
In 2009, Du, together with Wu Xin, authored the memoir Tu Mu Ri Xin (Chinese 木土日斤), documenting their early experiences working for Happy Camp. The title name of the novel is a word play on their names.
In 2013, Du and the Happy Family starred in the comedy film Bring Happiness Home. In 2015, Du featured on the variety show Takes a Real Man on Hunan TV.
Since Du began hosting Happy Camp, it was rumored that Du had been dating Wu Xin; the two later dismissed the rumors. In 2011, Du began dating Li Ruoxi. Since 2016, Du has been in a relationship with model and actress Shen Mengchen.[3]