Species of plant
A white flowering variety Dichroa febrifuga flowering plant in the family Hydrangeaceae .
National names
Traditional Chinese medicine
Dichroa febrifuga is an important herb in traditional Chinese medicine , where it is considered one of the 50 fundamental herbs .[ 2] alkaloids febrifugine and isofebrifugine are believed to be responsible for its antimalarial effects.[ 3] Glycyrrhiza glabra Ziziphus jujuba Zingiber officinale [ 4]
Potential drug against autoimmune disease
Halofuginone , sold under the brand name Halocur, is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine , a natural quinazolinone alkaloid which can be found in dichroa febrifuga .[ 5]
Halofuginone inhibits the development of T helper 17 cells , immune cells that play an important role in autoimmune disease , but it does not affect other kinds of T cells which are involved in normal immune function.[ 6] [ 7]
References
^ "Dichroa febrifuga " . Germplasm Resources Information Network Agricultural Research Service , United States Department of Agriculture . Retrieved 2008-02-05 .^ "Dichroa febrifuga - Plants For A Future database report" . Retrieved 2008-02-05 .^ Zhu, Shuren; Meng, Li; Zhang, Quan; Wei, Lai (2006). "Synthesis and evaluation of febrifugine analogues as potential antimalarial agents" . Bioorganic & Medicinal Chemistry Letters . 16 (7): 1854– 1858. doi :10.1016/j.bmcl.2006.01.009 . PMC 2072810 PMID 16434194 . ^ Rasoanaivo, Philippe; Wright, Colin W; Willcox, Merlin L; Gilbert, Ben (2011). "Whole plant extracts versus single compounds for the treatment of malaria: Synergy and positive interactions" . Malaria Journal . 10 (Suppl 1): S4. doi :10.1186/1475-2875-10-S1-S4 PMC 3059462 PMID 21411015 . ^ "Halofuginone hydrobromide" . NCI Drug Dictionary . National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services.^ Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, et al. (June 2009). "Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response" . Science . 324 (5932): 1334– 8. Bibcode :2009Sci...324.1334S . doi :10.1126/science.1172638 . PMC 2803727 PMID 19498172 . ^ Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A (June 2009). "Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response" . Science . 324 (5932): 1334– 8. Bibcode :2009Sci...324.1334S . doi :10.1126/science.1172638 . PMC 2803727 PMID 19498172 .
External links
