In 1934, Guerrero married Manuel Flores Leon Guerrero, who later became a Guamanian politician and Governor of Guam. They had seven children, Alfred Delfin (b.1935), Lolita Mariguita (1936-1982), Rudolpho Beltram (1938-1988), Evelyna Rebecca (b.1940), Teresita Recqual (b.1946), Manuel Flores (b.1947), and Patricia Christine (1953-1984). Guerrero and her family lived in Agana, Guam.[1][2][4]
Guerrero's daughter Lolita Leon Guerrero Huxel (1936-1982) became a Chamorro linguist and professor at University of Guam. She died in Hawaii.[5][6][7]
Guerrero's daughter Dr. Teresita L.G. Cottrell became a neuropsychologist.[8]
On January 5, 2004, Guerrero died in Guam. She was 88 years old. Guerrero is interred at Pigo Catholic Cemetery in Hagåtña, Guam.