DcuC family

C4-dicarboxylate anaerobic carrier
Identifiers
Symbol	DcuC
Pfam	PF03606
Pfam clan	CL0182
InterPro	IPR018385
TCDB	9.B.50
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The C₄-dicarboxylate uptake C family or DcuC family (TC# 2.A.61) is a family of transmembrane ion transporters found in bacteria.[1] A representative list of proteins belonging to the DcuC family can be found in the Transporter Classification Database.

An anaerobic C₄-dicarboxylate transporter (DcuC) of E. coli (TC# 2.A.61.1.1) has 14 putative transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. DcuC may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB in catalysing fumarate-succinate exchange and fumarate uptake.[2][3] DcuC shows the same transport modes as DcuA and DcuB (exchange, uptake, and presumably efflux of C4-dicarboxylates).[4][5]

The reactions probably catalyzed by the E. coli DcuC protein are:

1. C₄-dicarboxylate (out) + nH+ (out) → C₄-dicarboxylate (in) + nH+ (in)
2. C₄-dicarboxylate₁ (out) + C₄-dicarboxylate₂ (in) ⇌ C₄-dicarboxylate₁ (in) + C₄-dicarboxylate₂ (out).

See also

• Dicarboxylate
• Dcu family

References

1. Prakash, Shraddha; Cooper, Garret; Singhi, Soumya; Saier, Milton H. (2003-12-03). "The ion transporter superfamily". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. ISSN 0006-3002. PMID 14643936.
2. Engel P, Kramer R, Unden G (June 1994). "Transport of C4-dicarboxylates by anaerobically grown Escherichia coli. Energetics and mechanism of exchange, uptake and efflux". Eur. J. Biochem. 222 (2): 605–14. doi:10.1111/j.1432-1033.1994.tb18903.x. PMID 8020497.
3. Zientz E, Janausch IG, Six S, Unden G (June 1999). "Functioning of DcuC as the C4-dicarboxylate carrier during glucose fermentation by Escherichia coli". J. Bacteriol. 181 (12): 3716–20. doi:10.1128/JB.181.12.3716-3720.1999. PMC 93849. PMID 10368146.
4. Zientz E, Six S, Unden G (December 1996). "Identification of a third secondary carrier (DcuC) for anaerobic C4-dicarboxylate transport in Escherichia coli: roles of the three Dcu carriers in uptake and exchange". J. Bacteriol. 178 (24): 7241–7. doi:10.1128/jb.178.24.7241-7247.1996. PMC 178639. PMID 8955408.
5. "2.A.61 The C4-dicarboxylate Uptake C (DcuC) Family". Transporter Classification Database. Retrieved 2016-03-04.

This article incorporates text from the public domain Pfam and InterPro: IPR003606