Humphrey attended the Shawnee High School in Shawnee, Oklahoma.[1] He played both center and defensive line on the football team. Humphrey played in the 2017 U.S. Army All-American Game.[2] Humphrey was a highly-touted prospect, with a four-star rating from 247Sports. He was ranked 294th overall in his recruiting class, but was the 5th-best prospect from the State of Oklahoma and the 3rd-best center in the country.[3]
Humphrey redshirted his first year at Oklahoma in 2017.[6] He played in all 14 games with 12 starts in 2018.[7][8][9] He returned as the starting center for Oklahoma in 2019 and 2020, being named the Big 12 Conference's offensive lineman of the year in both seasons.[10][11] Following the 2020 season Humphrey announced he would be forgoing his final year of eligibility and declared for the 2021 NFL draft.[12]
Humphrey was selected by the Kansas City Chiefs in the second round (63rd overall) of the 2021 NFL draft.[15] On May 13, 2021, he signed his rookie contract with the Chiefs.[16] He made his first career start in the Chiefs week 1 game against the Cleveland Browns. On November 3, 2021, the midway point of the 2021 season, Pro Football Focus named Humphrey to their mid-season All-Rookie[17] and All-Pro teams.[18] He was named to the PFWA All-Rookie team.[19] In the 2022 season, Humphrey started in all 17 regular seasong games.[20] He helped the Chiefs win Super Bowl LVII against the Philadelphia Eagles 38–35, by anchoring the offensive line that allowed no sacks during the game.[21]
On August 22, 2024, Humphrey signed a four-year contract extension worth $72 million, $50 million of which was guaranteed. This new deal made him the highest-paid center in the NFL.[23]