Holland died from smallpox at the age of 36. He was engaged to the actress Jane Pope, but she broke off the engagement when she found him boating at Richmond with the actress Sophia Baddeley.[4][a] He was known for having affairs; the one with Mrs K. Earle led her husband, William Earle, to prosecute Holland successfully.[4]
^Garrick's epitaph on Holland runs "If Talents to make entertainment instructive to support the credit of the Stage by just and manly Action If to adorn Society by Virtues which would honour any Rank and Profession deserve remembrance Let Him with whom these Talents were long exerted To whom these Virtues were well known And by whom the loss of them will be long lamented bear testimony to the Worth and Abilities of his departed Friend Charles Holland who was born March 12, 1733 dy'd December 7, 1769 and was buried near this place. D. Garrick".[4]