She won the girls' singles title at the 2019 US Open. In the final, she defeated Alexandra Yepifanova, losing only one game. On the ITF Junior Circuit, Osorio advanced to the world No. 1 in September 2019.
2021: Maiden WTA Tour title, top 100, WTA 1000 & major debuts, Olympics
Osorio made her WTA 1000 debut at the 2021 BNP Paribas Open in Indian Wells.
In April 2021, while ranked world No. 180, Osorio won her first singles title at the Copa Colsanitas in her native Colombia, defeating Tamara Zidanšek in the final.[1][2]
She followed up with a semifinal appearance at the Charleston Open the following week.[3]
In May, she reached her third straight clay-court semifinal at the Serbia Open,[4] entering the top 100 as a result.[5]
She came through the qualifying at the French Open to make her Major debut.[6] However, she lost in the first round to Madison Brengle.
Osorio started at the US Open defeating Ivana Jorović in the first round of the tournament,[9] before losing to Ons Jabeur in the second.[10]
Osorio completed her first professional season by reaching the final of the Tenerife Open, where she eventually lost to Ann Li. She later revealed in an interview that she sustained an abdominal injury which affected her in the final round of the tournament.[11] Her success at the tournament saw her reach a new career high of No. 53 on 25 October 2021, finishing the season ranked No. 55.[12]
2022: Australian debut, first Grand Slam & WTA 1000 wins, top 35
Osorio gained direct acceptance at the Monterrey Open.
She reached her third WTA Tour-level singles final, losing to second seed and 2021 US Open runner-up, Leylah Fernandez, after having multiple match points.
She reached a career-high ranking of No. 33 on 4 April 2022.
2023: First Australian Open & Top 5 wins, WTA 1000 fourth round
Osorio gained direct acceptance at the Lyon Open. She reached her first semifinal of the season where she defeated local and third seed of the tournament, Alizé Cornet, in the first round, Jule Niemeier in the second round and Linda Nosková in the quarterfinals. She lost her semifinal match to top seed Caroline Garcia, in straight sets.
Ranked No. 70 at the Monterrey Open, Osorio retired in the first round in the second set against Mayar Sherif. As a result of not being able to defend her points from the previous year final, she fell 30 positions down to top 100 on 6 March 2023.
Ranked No. 115, she received a wildcard for the main draw of the Madrid Open. She reached the third round of a WTA 1000 for the first time in her career, defeating Clara Burel and 32nd seed Marta Kostyuk. She qualified for the next WTA 1000, the Italian Open, and won her first-round match against Varvara Gracheva, after saving three match points.[13] Next, she defeated 29th seed Petra Martić to reach back to back third rounds at a WTA 1000 level. She reached her first fourth round at a WTA 1000 level with a Top 5 win over Caroline Garcia, avenging her semifinal loss in Lyon and becoming the first Colombian woman to reach the round of 16 at a WTA 1000 tournament.[14] As a result, she returned to the top 85 on 22 May 2023.[15]
As the top qualifying seed, she entered the French Open as a lucky loser, and defeated Ana Bogdan in the first round.
2024: Second title at home, WTA 500 semifinal, back to top 65
At her home tournament, the Copa Colsanitas in Bogotá, Colombia, Osorio reached the semifinals for the third time, defeating qualifiers Marina Stakusic[16] and Anca Todoni[17] and then second seed and defending champion Tatjana Maria.[18] She reached her second final at the tournament defeating Sara Errani.[19] She lifted her second title at the tournament defeating top seed Marie Bouzková in straight sets. As a result, she returned to the top 65 in the rankings.[20][21]
(W) winner; (F) finalist; (SF) semifinalist; (QF) quarterfinalist; (#R) rounds 4, 3, 2, 1; (RR) round-robin stage; (Q#) qualification round; (P#) preliminary round; (DNQ) did not qualify; (A) absent; (Z#) Davis/Fed Cup Zonal Group (with number indication) or (PO) play-off; (G) gold, (S) silver or (B) bronze Olympic/Paralympic medal; (NMS) not a Masters tournament; (NTI) not a Tier I tournament; (P) postponed; (NH) not held; (SR) strike rate (events won / competed); (W–L) win–loss record.
To avoid confusion and double counting, these charts are updated at the conclusion of a tournament or when the player's participation has ended.
Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup/Billie Jean King Cup and Olympic Games are included in win–loss records.[31]
^Edition is split into the two years due to COVID-19.
^ abThe first Premier 5 event of the year has switched back and forth between the Dubai Tennis Championships and the Qatar Ladies Open since 2009. Dubai was classified as a Premier 5 event from 2009 to 2011 before being succeeded by Doha for the 2012–2014 period. In 2015, Dubai regained its Premier 5 status while Doha was demoted to Premier status. The two tournaments have since alternated status every year. The Premier 5 tournaments were reclassified as WTA 1000 tournaments in 2021.
^ abcDuring the season, she did not play in the main draw of any tour-level tournaments. However, she played at the Billie Jean King Cup, which is not counted as a played tournament but matches counted.