The route begins at SR 37 in Sears Point, and then runs past the Tolay Lake basin and across Tolay Creek near Infineon Raceway. As it continues northward through Sonoma County, it meets SR 116, where it then veers east. SR 121 then enters Schellville, where it begins a short overlap with SR 12. Upon leaving, it begins another overlap with SR 29, which happens to be a freeway, in Napa County. When it leaves, it continues northward and meets SR 221 in Napa. As it leaves the city, it continues northward for several miles before reaching its north end at SR 128 near Lake Berryessa.
The section from SR 37 to SR 29 in Napa remains virtually unchanged since its definition in 1963. The northern section, however, was slightly altered since its definition the same year due to a realignment of various other freeways.[8]
Major intersections
Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, based on the alignment that existed at the time, and do not necessarily reflect current mileage. R reflects a realignment in the route since then, M indicates a second realignment, L refers to an overlap due to a correction or change, and T indicates postmiles classified as temporary (for a full list of prefixes, see California postmile § Official postmile definitions).[1] Segments that remain unconstructed or have been relinquished to local control may be omitted. The numbers reset at county lines; the start and end postmiles in each county are given in the county column.
^ abCalifornia Department of Transportation. "State Truck Route List". Sacramento: California Department of Transportation. Archived from the original(XLS file) on September 5, 2015. Retrieved June 30, 2015.
^"Article 2 of Chapter 2 of Division 1". California Streets and Highways Code. Sacramento: California Office of Legislative Counsel. Retrieved February 6, 2019.
^Natzke, Stefan; Neathery, Mike & Adderly, Kevin (June 20, 2012). "What is the National Highway System?". National Highway System. Washington, DC: Federal Highway Administration. Retrieved July 1, 2012.