CHST1

CHST1
Identifiers
Aliases	CHST1, C6ST, GST-1, KS6ST, KSGal6ST, KSST, carbohydrate sulfotransferase 1
External IDs	OMIM: 603797; MGI: 1924219; HomoloGene: 2711; GeneCards: CHST1; OMA:CHST1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p11.2 Start 45,647,689 bp[1] End 45,665,622 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E1 Start 92,430,052 bp[2] End 92,445,595 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole Brodmann area 10 middle frontal gyrus Parietal Lobe Amygdala anterior cingulate cortex right frontal lobe postcentral gyrus orbitofrontal cortex dorsolateral prefrontal cortex Top expressed in lacrimal gland molar habenula olfactory tubercle subiculum Temporal Lobe prefrontal cortex nucleus accumbens primary motor cortex anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity N-acetylglucosamine 6-O-sulfotransferase activity keratan sulfotransferase activity Cellular component Golgi membrane Golgi apparatus membrane integral component of membrane trans-Golgi network Biological process sulfur compound metabolic process galactose metabolic process inflammatory response keratan sulfate biosynthetic process polysaccharide metabolic process keratan sulfate metabolic process carbohydrate metabolic process N-acetylglucosamine metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8534 76969 Ensembl ENSG00000175264 ENSMUSG00000027221 UniProt O43916 Q9EQC0 RefSeq (mRNA) NM_003654 NM_023850 NM_001356552 NM_001356553 RefSeq (protein) NP_003645 NP_076339 NP_001343481 NP_001343482 Location (UCSC) Chr 11: 45.65 – 45.67 Mb Chr 2: 92.43 – 92.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.[5][6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000175264 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027221 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fukuta M, Inazawa J, Torii T, Tsuzuki K, Shimada E, Habuchi O (Jan 1998). "Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase". J Biol Chem. 272 (51): 32321–8. doi:10.1074/jbc.272.51.32321. PMID 9405439.
6. Mazany KD, Peng T, Watson CE, Tabas I, Williams KJ (Aug 1998). "Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization". Biochim Biophys Acta. 1407 (1): 92–7. doi:10.1016/s0925-4439(98)00028-3. PMID 9639683.
7. "Entrez Gene: CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1".

External links

• Human CHST1 genome location and CHST1 gene details page in the UCSC Genome Browser.

Further reading

• Williams KJ (1997). "Atherosclerosis: cell biology and lipoproteins". Curr. Opin. Lipidol. 7 (6): U202–8. doi:10.1097/00041433-199612000-00016. PMID 9117134.
• Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12): 6953–9. doi:10.1128/JVI.66.12.6953-6959.1992. PMC 240329. PMID 1433500.
• Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2): 943–52. doi:10.1128/JVI.67.2.943-952.1993. PMC 237448. PMID 8419650.
• Li X, Tedder TF (1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization". Genomics. 55 (3): 345–7. doi:10.1006/geno.1998.5653. PMID 10049591.
• Bistrup A, Bhakta S, Lee JK, et al. (1999). "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin". J. Cell Biol. 145 (4): 899–910. doi:10.1083/jcb.145.4.899. PMC 2133194. PMID 10330415.
• Tu L, Murphy PG, Li X, Tedder TF (1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1". J. Immunol. 163 (9): 5070–8. doi:10.4049/jimmunol.163.9.5070. PMID 10528213.
• Torii T, Fukuta M, Habuchi O (2000). "Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase". Glycobiology. 10 (2): 203–11. doi:10.1093/glycob/10.2.203. PMID 10642612.
• Li X, Tu L, Murphy PG, et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin". J. Leukoc. Biol. 69 (4): 565–74. doi:10.1189/jlb.69.4.565. PMID 11310842. S2CID 8888883.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yamada T, Ohtake S, Sato M, Habuchi O (2005). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues". Biochem. J. 384 (Pt 3): 567–75. doi:10.1042/BJ20040965. PMC 1134142. PMID 15324304.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Liu J, Chau CH, Liu H, et al. (2006). "Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth". J. Cell Sci. 119 (Pt 5): 933–42. doi:10.1242/jcs.02796. hdl:10722/44575. PMID 16495484.
• Kitayama K, Hayashida Y, Nishida K, Akama TO (2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans". J. Biol. Chem. 282 (41): 30085–96. doi:10.1074/jbc.M703695200. PMID 17690104.