Founded on 31 October 1962, San Antonio won their first title in the Primera A AFC only in 2021.[2] They first appeared in the Copa Simón Bolívar in that year, being knocked out in the quarterfinals by García Agreda.[3]
After winning the Primera A title again in 2022, the club qualified to the 2023 Copa Simón Bolívar. In that competition, they reached the finals, facing GV San José,[4] but lost the title on penalties.[5] Six days after losing the title, however, they achieved promotion to the Primera División for the first time ever, after winning the promotion/relegation play-offs against Libertad Gran Mamoré.[6]
In their first participation in the top flight, San Antonio managed to reach the finals of the 2024 Apertura tournament, after advancing as runners-up in their group and defeating Bolívar in the quarter-finals and Independiente Petrolero in the semi-finals. In the final series, they beat Universitario de Vinto 3–2 on aggregate, thus qualifying for the championship final at the end of the season as well as the 2025 Copa Libertadores group stage.[7]
Current squad
As of 19 April 2024
Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.