Bromsulfthalein

Bromsulfthalein
Names
Preferred IUPAC name
Disodium 3,3′-(4,5,6,7-tetrabromo-3-oxo-2-benzofuran-1,1(3H)-diyl)bis(6-hydroxybenzene-1-sulfonate)
Other names
Bromsulphthalein; Bromosulfophthalein; Bromosulphophthalein; BSP; Sulfobromophthalein
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.005.498 Edit this at Wikidata
UNII
  • InChI=1S/C20H10Br4O10S2.2Na/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;/q;2*+1/p-2 checkY
    Key: GHAFORRTMVIXHS-UHFFFAOYSA-L checkY
  • InChI=1/C20H10Br4O10S2.2Na/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;/q;2*+1/p-2
    Key: GHAFORRTMVIXHS-NUQVWONBAX
  • [Na+].[Na+].[O-]S(=O)(=O)c1c(O)ccc(c1)C3(OC(=O)c2c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O
Properties
C20H8Br4Na2O10S2
Molar mass 837.99 g·mol−1
Pharmacology
V04CE02 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Bromsulfthalein (also known as bromsulphthalein, bromosulfophthalein, and BSP) is a phthalein dye used in liver function tests. Determining the rate of removal of the dye from the blood stream gives a measure of liver function.[1] The mechanism by which the liver detoxifies BSP is to attach it to glutathione which is the body’s master antioxidant.

References

  1. ^ Rosenthal, Sanford M. (1925). "Clinical Application of the Bromsulphalein Test for Hepatic Function". JAMA: The Journal of the American Medical Association. 84 (15): 1112. doi:10.1001/jama.1925.02660410020008.
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