The context of Bott periodicity is that the homotopy groups of spheres, which would be expected to play the basic part in algebraic topology by analogy with homology theory, have proved elusive (and the theory is complicated). The subject of stable homotopy theory was conceived as a simplification, by introducing the suspension (smash product with a circle) operation, and seeing what (roughly speaking) remained of homotopy theory once one was allowed to suspend both sides of an equation as many times as one wished. The stable theory was still hard to compute with, in practice.
What Bott periodicity offered was an insight into some highly non-trivial spaces, with central status in topology because of the connection of their cohomology with characteristic classes, for which all the (unstable) homotopy groups could be calculated. These spaces are the (infinite, or stable) unitary, orthogonal and symplectic groups U, O and Sp. In this context, stable refers to taking the union U (also known as the direct limit) of the sequence of inclusions
and similarly for O and Sp. Note that Bott's use of the word stable in the title of his seminal paper refers to these stable classical groups and not to stable homotopy groups.
The important connection of Bott periodicity with the stable homotopy groups of spheres comes via the so-called stable J-homomorphism from the (unstable) homotopy groups of the (stable) classical groups to these stable homotopy groups . Originally described by George W. Whitehead, it became the subject of the famous Adams conjecture (1963) which was finally resolved in the affirmative by Daniel Quillen (1971).
Bott's original results may be succinctly summarized in:
Corollary: The (unstable) homotopy groups of the (infinite) classical groups are periodic:
Note: The second and third of these isomorphisms intertwine to give the 8-fold periodicity results:
Loop spaces and classifying spaces
For the theory associated to the infinite unitary group, U, the space BU is the classifying space for stable complex vector bundles (a Grassmannian in infinite dimensions). One formulation of Bott periodicity describes the twofold loop space, of BU. Here, is the loop space functor, right adjoint to suspension and left adjoint to the classifying space construction. Bott periodicity states that this double loop space is essentially BU again; more precisely,
is essentially (that is, homotopy equivalent to) the union of a countable number of copies of BU. An equivalent formulation is
Either of these has the immediate effect of showing why (complex) topological K-theory is a 2-fold periodic theory.
In the corresponding theory for the infinite orthogonal group, O, the space BO is the classifying space for stable real vector bundles. In this case, Bott periodicity states that, for the 8-fold loop space,
or equivalently,
which yields the consequence that KO-theory is an 8-fold periodic theory. Also, for the infinite symplectic group, Sp, the space BSp is the classifying space for stable quaternionic vector bundles, and Bott periodicity states that
or equivalently
Thus both topological real K-theory (also known as KO-theory) and topological quaternionic K-theory (also known as KSp-theory) are 8-fold periodic theories.
Geometric model of loop spaces
One elegant formulation of Bott periodicity makes use of the observation that there are natural embeddings (as closed subgroups) between the classical groups. The loop spaces in Bott periodicity are then homotopy equivalent to the symmetric spaces of successive quotients, with additional discrete factors of Z.
The resulting spaces are homotopy equivalent to the classical reductive symmetric spaces, and are the successive quotients of the terms of the Bott periodicity clock. These equivalences immediately yield the Bott periodicity theorems.
^The interpretation and labeling is slightly incorrect, and refers to irreducible symmetric spaces, while these are the more general reductive spaces. For example, SU/Sp is irreducible, while U/Sp is reductive. As these show, the difference can be interpreted as whether or not one includes orientation.