Comber's first broadcasts were in excerpts from the show Clowns in Clover, and he made more regular appearances as a comedian on BBC radio from 1929, sometimes with Paul England, Claude Hulbert and Eddie Childs (later replaced by Arthur Clay, and subsequently by H. B. Longhurst) as "Those Four Chaps". He also performed in a double act with Hulbert, and recorded light comedy songs, such as a cleaned-up version of "Barnacle Bill".[4] He appeared in films, including Elstree Calling (1930), Lazybones (1935), and Be Careful, Mr. Smith (1935).
The BBC's entertainment programmes were broadcast from north Wales during the Second World War, and Comber died there, in Bangor, in 1942 aged 56.