Barbara Illingworth Brown

Barbara Illingworth Brown
Born	Barbara A. Illingworth May 12, 1924[1] Hartford, CT
Died	September 27, 2016[1]
Alma mater	Yale University
Scientific career
Thesis	Effects of purified growth hormone on glycogen storage (1950)
Doctoral advisor	Jane Anne Russell

Barbara Illingworth Brown was an American biochemist. She worked primarily at Washington University in St. Louis.

Education and career

Brown was born in Hartford, Connecticut and later moved to Pennsylvania when her father's job in insurance moved the family.[2] Brown graduated from Smith College in 1946. She worked with Jane Anne Russell at Yale University[2] and received her PhD in physiological chemistry in 1950.[3][4] Following her Ph.D., Brown applied to work with the Nobel Prize-winner Gerty Cori[2] and became a Research Associate Professor of Biochemistry at Washington University in St. Louis and Established Investigator of the American Heart Association.[5] She later also worked with Cori's husband and fellow Nobel Prize winner Carl Ferdinand Cori.[2] She retired in 1989.[2]

Brown served on the National Advisory General Medical Sciences Council at the National Institutes of Health from 1972 to 1974.[6] She was awarded the Wilbur Cross Medal from Yale in 1983.[7]

Research

Her work was primarily devoted to the biochemistry of inherited metabolic diseases.[1] She investigated the structure of glycogen and amylopectins,[2][8] and defined the pathway and mechanisms of phosphorylase enzymes.[9][10] Her research included the discovery of enzymes[11] in a previously unknown pathway to process glycogen.[12] She went on to research diseases related to the storage of glycogen where these enzymes were absent.[13][14] She applied some of Carl Cori's findings to medical cases,[15] and confirmed the second known case of fructose bisphosphatase deficiency, a rare metabolic disorder, in 1970.[16][17] She played a similar role in therapeutic research into glycogen storage disease type I.[18][19]

Personal life

Her husband, David H. Brown, was also a scientist and they collaborated on research on polysaccharide synthesis and glycogen storage diseases.[2]

Selected publications

• ILLINGWORTH, BARBARA A; RUSSELL, JANE A (1951). "The Effects of Growth Hormone on Glycogen in Tissues of the Rat1". Endocrinology. 48 (4): 423–434. doi:10.1210/endo-48-4-423. ISSN 0013-7227. OCLC 4631825308. PMID 14831545.
• Illingworth, Barbara; Jansz, Hendrik S.; Brown, David H.; Cori, Carl F. (1958-12-15). "Observations on the Function of Pyridoxal-5-Phosphate in Phosphorylase". Proceedings of the National Academy of Sciences. 44 (12): 1180–1191. Bibcode:1958PNAS...44.1180I. doi:10.1073/pnas.44.12.1180. ISSN 0027-8424. PMC 528705. PMID 16590330.
• Illingworth, Barbara; Brown, David H.; Cori, Carl F. (1961-04-01). "The De Novo Synthesis of Polysaccharide by Phosphorylase". Proceedings of the National Academy of Sciences. 47 (4): 469–478. Bibcode:1961PNAS...47..469I. doi:10.1073/pnas.47.4.469. ISSN 0027-8424. PMC 221475. PMID 13717528.
• Eberlein, Walter R; Illingworth, Barbara A; Sidbury, James B (1962). "Heterogeneous glycogen storage disease in siblings and favorable response to synthetic androgen administration". AJM the American Journal of Medicine. 33 (1): 20–26. doi:10.1016/0002-9343(62)90273-5. ISSN 0002-9343. OCLC 4922525423. PMID 13889017.
• Brown, Barbara Illingworth; Brown, David H (1966). "Lack of an α -1,4-Glucan: α -1,4-Glucan 6-glycosyl Transferase in a Case of Type IV Glycogenosis". Proceedings of the National Academy of Sciences of the United States of America. 56 (2): 725–729. Bibcode:1966PNAS...56..725B. doi:10.1073/pnas.56.2.725. ISSN 0027-8424. OCLC 5554094258. PMC 224432. PMID 5229990.

References

1. "Brown, Barbara "Bobbie" (Illingworth)". madison.com. October 1, 2016.
2. Exton, John H. (2013). "Contributions of Barbara and David Brown". Crucible of science : the story of the Cori laboratory. New York: Oxford University Press. pp. 161–164. ISBN 978-0-19-986108-8. OCLC 843881801.
3. Illingworth, Barbara A (1950). Effects of purified growth hormone on glycogen storage. New Haven. OCLC 42655887.
4. "Wilbur Cross Medalists by Department" (PDF). Yale Graduate School of Arts and Sciences. Archived from the original (PDF) on 2021-04-14. Retrieved 2021-02-13.
5. "Washington University School of Medicine Bulletin". 1967. {{cite journal}}: Cite journal requires |journal= (help)
6. "Dr. Brown Appointed to Council" (PDF). The NIH Record. 24 (4): 8. February 15, 1972.
7. "List of Past Wilbur Cross Recipients | Yale Graduate School of Arts & Sciences". gsas.yale.edu.
8. Illingworth, Barbara; Larner, Joseph; Cori, Gerty T. (1952-12-01). "Structure of Glycogens and Amylopectins: I. Enzymatic Determination of Chain Length*". Journal of Biological Chemistry. 199 (2): 631–640. doi:10.1016/S0021-9258(18)38501-6. ISSN 0021-9258. PMID 13022670.
9. Illingworth, Barbara; Brown, David H.; Cori, Carl F. (1961-04-01). "The De Novo Synthesis of Polysaccharide by Phosphorylase". Proceedings of the National Academy of Sciences. 47 (4): 469–478. Bibcode:1961PNAS...47..469I. doi:10.1073/pnas.47.4.469. ISSN 0027-8424. PMC 221475. PMID 13717528.
10. Illingworth, Barbara; Jansz, Hendrik S.; Brown, David H.; Cori, Carl F. (1958-12-15). "Observations on the Function of Pyridoxal-5-Phosphate in Phosphorylase". Proceedings of the National Academy of Sciences. 44 (12): 1180–1191. Bibcode:1958PNAS...44.1180I. doi:10.1073/pnas.44.12.1180. ISSN 0027-8424. PMC 528705. PMID 16590330.
11. Brown, David H.; Illingworth, Barbara (1962-10-01). "The Properties of an Oligo-1,4 → 1,4-Glucantransferase from Animal Tissues". Proceedings of the National Academy of Sciences. 48 (10): 1783–1787. Bibcode:1962PNAS...48.1783B. doi:10.1073/pnas.48.10.1783. ISSN 0027-8424. PMC 221040. PMID 14015933.
12. Brown, David H.; Illingworth, Barbara; Cori, Carl F. (1963). "Enzymatic Debranching of Glycogen: Combined Action of Oligo-1,4→1,4-glucan-transferase and Amylo-1,6-glucosidase in Debranching Glycogen". Nature. 197 (4871): 980–982. Bibcode:1963Natur.197..980B. doi:10.1038/197980a0. ISSN 1476-4687. PMID 14015932. S2CID 4161911.
13. Hauk, Rosalind; Illingworth, Barbara; Brown, David H.; Cori, Carl F. (1959-06-01). "Enzymes of glycogen synthesis in glycogen-deposition disease". Biochimica et Biophysica Acta. 33 (2): 554–556. doi:10.1016/0006-3002(59)90149-0. ISSN 0006-3002. PMID 13670930.
14. Illingworth, Barbara; Kornfeld, Rosalind; Brown, David H. (1960). "Phosphorylase and uridinediphosphoglucose-glycogen transferase in pyridoxine deficiency". Biochimica et Biophysica Acta. 42: 486–489. doi:10.1016/0006-3002(60)90827-1. PMID 13717529.
15. Correspondence with Carl Cori, David and Barbara Brown Papers, Collection FC179, Becker Archives, Washington University School of Medicine.
16. Brockhoff, Dorothy (Spring 1971). "Her Present Is Her Health". Outlook Magazine. 8 (2): 16–18.
17. Pagliara, Anthony S.; Karl, Irene E.; Keating, James P.; Brown, Barbara I.; Kipnis, David M. (1 August 1972). "Hepatic fructose-1,6-diphosphatase deficiency: A cause of lactic acidosis and hypoglycemia in infancy". The Journal of Clinical Investigation. 51 (8): 2115–2123. doi:10.1172/JCI107018. ISSN 0021-9738. PMC 292368. PMID 4341015.
18. Malatack, J. Jeffrey; Finegold, David N.; Iwatsuki, Shunzaburo; Shaw, Byers W.; Gartner, J. Carlton; Zitelli, Basil J.; Roe, Thomas; Starzl, Thomas E. (14 May 1983). "Liver Transplantation for Type I Glycogen Storage Disease". Lancet. 1 (8333): 1073–1075. doi:10.1016/s0140-6736(83)91910-4. ISSN 0140-6736. PMC 3022514. PMID 6133106.
19. Starzl, T E; Putnam, C W; Porter, K A; Halgrimson, C G; Corman, J; Brown, B I; Gotlin, R W; Rodgerson, D O; Greene, H L (October 1973). "Portal diversion for the treatment of glycogen storage disease in humans". Annals of Surgery. 178 (4): 525–539. doi:10.1097/00000658-197310000-00015. ISSN 0003-4932. PMC 1355694. PMID 4517839.