BRE (gene)

BABAM2
Identifiers
Aliases	BABAM2, BRCC4, BRCC45, BRE, brain and reproductive organ-expressed (TNFRSF1A modulator), BRISC and BRCA1 A complex member 2
External IDs	OMIM: 610497; MGI: 1333875; HomoloGene: 3604; GeneCards: BABAM2; OMA:BABAM2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.2 Start 27,889,941 bp[1] End 28,338,901 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 31,855,028 bp[2] End 32,242,306 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal cortex right adrenal cortex gastrocnemius muscle right auricle popliteal artery tibial arteries left ventricle muscle of thigh anterior pituitary Top expressed in lens transitional epithelium of urinary bladder adrenal gland ankle brown adipose tissue granulocyte epithelium of lens left lobe of liver muscle of thigh epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peroxisome targeting sequence binding polyubiquitin modification-dependent protein binding protein binding tumor necrosis factor receptor binding Cellular component nuclear ubiquitin ligase complex nucleoplasm nucleus cytoplasm cytosol BRCA1-A complex BRISC complex Biological process response to ionizing radiation positive regulation of DNA repair cell division protein K63-linked deubiquitination cell cycle double-strand break repair via nonhomologous end joining signal transduction apoptotic process DNA repair cellular response to DNA damage stimulus double-strand break repair protein deubiquitination negative regulation of apoptotic process mitotic G2 DNA damage checkpoint signaling chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9577 107976 Ensembl ENSG00000158019 ENSMUSG00000052139 UniProt Q9NXR7 Q8K3W0 RefSeq (mRNA) NM_001261840 NM_001329112 NM_001329113 NM_001329114 NM_001329115 NM_004899 NM_199191 NM_199192 NM_199193 NM_199194 NM_144541 NM_181279 NM_181280 NM_181281 NM_181282 RefSeq (protein) NP_001248769 NP_001316041 NP_001316042 NP_001316043 NP_001316044 NP_004890 NP_954661 NP_954662 NP_954663 NP_954664 NP_653124 NP_851796 NP_851797 NP_851798 NP_851799 Location (UCSC) Chr 2: 27.89 – 28.34 Mb Chr 5: 31.86 – 32.24 Mb PubMed search [3] [4]
Wikidata
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BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.[5][6][7]

Repair of DNA damage

BRE, the protein product of the BRE (gene), is a core component of the deubiquitin complex BRCA1-A.[8] Other core components of the BRCA1-A complex are the BRCC36 protein (BRCC3 gene), MERIT40 protein (BABAM1 gene), and RAP80 protein (UIMC1 gene).[8]

BRCA1, as distinct from BRCA1-A, is employed in the repair of chromosomal damage with an important role in the error-free homologous recombinational (HR) repair of DNA double-strand breaks. Sequestration of BRCA1 away from the DNA damage site suppresses homologous recombination and redirects the cell in the direction of repair by the process of non-homologous end joining (NHEJ).[8] The role of BRCA1-A appears to be to bind BRCA1 with high affinity and withdraw it away from the site of DNA damage to the periphery where it remains sequestered, thus promoting NHEJ in preference to HR.

Protein-protein interactions

BRE (gene) has been shown to interact with:

• BARD1,[9]
• BRCA1,[9]
• BRCA2,[9]
• BRCC3,[9][10]
• C19orf62,[10][11]
• P53,[9] and
• RAD51.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000158019 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052139 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gu C, Castellino A, Chan JY, Chao MV (September 1998). "BRE: a modulator of TNF-alpha action". FASEB Journal. 12 (12): 1101–1108. doi:10.1096/fasebj.12.12.1101. PMID 9737713. S2CID 83491319.
6. Li L, Yoo H, Becker FF, Ali-Osman F, Chan JY (January 1995). "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid". Biochemical and Biophysical Research Communications. 206 (2): 764–774. doi:10.1006/bbrc.1995.1108. PMID 7826398.
7. "Entrez Gene: BRE brain and reproductive organ-expressed (TNFRSF1A modulator)".
8. Rabl J (October 2020). "BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling". Biomolecules. 10 (11): 1503. doi:10.3390/biom10111503. PMC 7692841. PMID 33142801.
9. Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, et al. (November 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell. 12 (5): 1087–1099. doi:10.1016/s1097-2765(03)00424-6. PMID 14636569.
10. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
11. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• Human BRE genome location and BRE gene details page in the UCSC Genome Browser.

Further reading

• Miao J, Panesar NS, Chan KT, Lai FM, Xia N, Wang Y, et al. (April 2001). "Differential expression of a stress-modulating gene, BRE, in the adrenal gland, in adrenal neoplasia, and in abnormal adrenal tissues". The Journal of Histochemistry and Cytochemistry. 49 (4): 491–500. doi:10.1177/002215540104900409. PMID 11259452.
• Ching AK, Li PS, Li Q, Chan BC, Chan JY, Lim PL, et al. (November 2001). "Expression of human BRE in multiple isoforms". Biochemical and Biophysical Research Communications. 288 (3): 535–545. doi:10.1006/bbrc.2001.5801. PMID 11676476.
• Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, et al. (November 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell. 12 (5): 1087–1099. doi:10.1016/S1097-2765(03)00424-6. PMID 14636569.
• Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC, et al. (December 2004). "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway". The Journal of Biological Chemistry. 279 (50): 52106–52116. doi:10.1074/jbc.M408678200. PMID 15465831.
• Chan BC, Li Q, Chow SK, Ching AK, Liew CT, Lim PL, et al. (January 2005). "BRE enhances in vivo growth of tumor cells". Biochemical and Biophysical Research Communications. 326 (2): 268–273. doi:10.1016/j.bbrc.2004.11.013. PMID 15582573.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.