Aryl-aldehyde dehydrogenase (NADP+)

aryl-aldehyde dehydrogenase (NADP+)
Identifiers
EC no.	1.2.1.30
CAS no.	9074-94-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an aryl-aldehyde dehydrogenase (NADP+) (EC 1.2.1.30) is an enzyme that catalyzes the chemical reaction

an aromatic aldehyde + NADP^+ + AMP + diphosphate + H₂O ${\displaystyle \rightleftharpoons }$ an aromatic acid + NADPH + H^+ + ATP

The 5 substrates of this enzyme are aromatic aldehyde, NADP^+, AMP, diphosphate, and H₂O, whereas its 4 products are aromatic acid, NADPH, H^+, and ATP.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aryl-aldehyde:NADP+ oxidoreductase (ATP-forming). Other names in common use include aromatic acid reductase, and aryl-aldehyde dehydrogenase (NADP+).

References

• Gross GG (1972). "Formation and reduction of intermediate acyladenylate by aryl-aldehyde. NADP oxidoreductase from Neurospora crassa". Eur. J. Biochem. 31 (3): 585–92. doi:10.1111/j.1432-1033.1972.tb02569.x. PMID 4405494.
• Gross GG, Zenk MH (1969). "[Reduction of aromatic acids to aldehydes and alcohols in the cell-free system. 1. Purification and properties of aryl-aldehyde: NADP-oxidoreductase from Neurospora crassa]". Eur. J. Biochem. 8 (3): 413–9. doi:10.1111/j.1432-1033.1969.tb00543.x. PMID 4389863.