Aryl-aldehyde dehydrogenase

aryl-aldehyde dehydrogenase
Identifiers
EC no.	1.2.1.29
CAS no.	37250-94-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an aryl-aldehyde dehydrogenase (EC 1.2.1.29) is an enzyme that catalyzes the chemical reaction

an aromatic aldehyde + NAD^+ + H₂O ${\displaystyle \rightleftharpoons }$ an aromatic acid + NADH + H^+

The 3 substrates of this enzyme are aromatic aldehyde, NAD^+, and H₂O, whereas its 3 products are aromatic acid, NADH, and H^+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aryl-aldehyde:NAD+ oxidoreductase. This enzyme participates in tyrosine metabolism and biphenyl degradation.

References

• Raison JK, Henson G, Rienits KG (1966). "The oxidation of gentisaldehyde by nicotinamide-adenine dinucleotide-specific, aromatic aldehyde dehydrogenase from rabbit liver". Biochim. Biophys. Acta. 118 (2): 285–98. doi:10.1016/s0926-6593(66)80037-1. PMID 4289834.