The Apostolic Vicariate (or Vicariate Apostolic) of Tucupita (Latin: Apostolicus Vicariatus Tucupitensis) is a missionary circonscription of the Roman Catholic Church in Venezuela.
It is exempt, i.e. directly dependent on the Holy See, not part of any ecclesiastical province. Its cathedral see is located in Tucupita, the city capital of Venezuela's Atlantic-coastal Delta Amacuro state.