Costello has been an advocate for PSA testing in men and robotic surgery for prostate removal in treating prostate cancer. Based on microdissections of cadavers, he described the anatomy of the nerves near the prostate, significant for preserving erectile function.
In 1981 Costello completed a fellowship at MD Anderson Cancer Center in Houston, under the supervision of urological surgeon Douglas E. Johnson. Subsequently, he spent five years back in Melbourne and then took a sabbatical as a returning fellow in Houston in 1989, when he developed an interest in emerging technologies relating to prostate cancer. He then returned to Melbourne in 1990 and became head of the unit at St. Vincent's.[1][2][3]
He established an international urologic-oncology fellowship programme.[4] In 1992, he published the first series of men who had laser surgery for benign prostate enlargements using the Nd:YAG laser.[5] In 1999, he was appointed head of urology at the Royal Melbourne Hospital, where, in 2001, he established a laboratory for prostate cancer research at its Department of Surgery. He also helped establish the Victorian Prostate Cancer Foundation.[1][6]
In 2003, he began using the da Vinci Surgical robot for prostate surgery at his private practice in Epworth Hospital in Richmond, and established the first robotic prostate cancer surgery programme in Australia.[1][4]
In 2015, he became a member of the Order of Australia “for significant service to medicine in the field of urology as a clinician, administrator and author, to cancer research, and to medical education”.[17] The following year he became the first honorary life member of Irish Association of Urologists.[17]
As a student Costello had been captain of football and swimming teams and later took up running. Of his siblings, four became doctors, one a judge and one a teacher.[1]
In his 30s, he owned a vineyard and made wine. He is married and has grandchildren.[1]
Murphy, Declan G.; Agarwal, Dinesh; Costello, Anthony J. (1 February 2009). "Anterior retraction of the prostate during robotic-assisted laparoscopic radical prostatectomy using the closure device". BJU International. 103 (4): 558–562. doi:10.1111/j.1464-410X.2009.08393.x. ISSN1464-4096. PMID19187352. S2CID46485867.
^Lerner, Lori B.; Shirk, Joseph; Nimeh, Tony (2014). "9. Holmium Ablation of Prostate". In Bilal Chughtai, Bilal; Te, Alexis E.; Kaplan, Steven A. (eds.). Treatment of Benign Prostatic Hyperplasia: Modern Alternative to Transurethral Resection of the Prostate. Springer. p. 49. ISBN978-1-4939-1586-6.
^McLoughlin, John; Burgess, Neil; Motiwala, Hanif; Speakman, Mark J.; Doble, Andrew; Kelly, John (4 March 2013). Top Tips in Urology. John Wiley & Sons. ISBN978-0-470-67293-8.