Alezzandrini syndrome

Alezzandrini syndrome
SpecialtyDermatology
SymptomsLoss of vision, facial vitiligo, sound sensitivity
CausesUnknown
TreatmentNone
DeathsUnknown

Alezzandrini syndrome is a very rare syndrome characterized by a unilateral degenerative retinitis, followed after several months by ipsilateral vitiligo on the face and ipsilateral poliosis.[1]: 864 [2] Deafness may also be present.[1]: 864 [3]

Signs and symptoms

Initially, there is a progressive loss of visual acuity, mostly in one eye. Infected areas experience pigmentation loss in the skin and hair. Unilateral tapetoretinal degeneration accompanied by the ipsilateral appearance of facial vitiligo and poliosis is the hallmark of Alezzandrini syndrome.[4]

Causes

It is unknown what causes Alezzandrini syndrome.[4]

Diagnosis

The clinical presentation is the basis for the diagnosis.[4]

Treatment

Psoralen plus ultraviolet A (PUVA) treatment is an option for cases with extensive depigmentation. Topical steroids may be used to treat vitiligo in specific areas. People who have vitiligo should wear sunscreen to avoid getting sunburned and developing skin cancer later on.[4]

See also

References

  1. ^ a b James W, Berger T, Elston D (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. ISBN 0-7216-2921-0.
  2. ^ Gupta M, Pande D, Lehl SS, Sachdev A (August 2011). "Alezzandrini syndrome". BMJ Case Reports. 2011 (aug17 1): bcr0420114052. doi:10.1136/bcr.04.2011.4052. PMC 3171053. PMID 22688932.
  3. ^ Rapini RP, Bolognia JL, Jorizzo JL (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 918. ISBN 978-1-4160-2999-1.
  4. ^ a b c d Janniger, Camila K (June 8, 2022). "Alezzandrini Syndrome: Practice Essentials, Pathophysiology, Epidemiology". Medscape Reference. Retrieved January 24, 2024.