ATP6V0D2

ATP6V0D2
Identifiers
Aliases	ATP6V0D2, ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2, ATP6D2, VMA6, ATPase H+ transporting V0 subunit d2
External IDs	OMIM: 618072; MGI: 1924415; HomoloGene: 72090; GeneCards: ATP6V0D2; OMA:ATP6V0D2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q21.3 Start 85,987,323 bp[1] End 86,154,225 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A3 Start 19,876,841 bp[2] End 19,922,605 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in human kidney buccal mucosa cell amniotic fluid renal medulla testicle rectum tibia muscle of thigh mucosa of transverse colon skin of hip Top expressed in lumbar spinal ganglion submandibular gland body of femur parotid gland decidua right kidney calvaria human kidney right lung right lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding proton transmembrane transporter activity P-type proton-exporting transporter activity proton-transporting ATPase activity, rotational mechanism Cellular component proton-transporting V-type ATPase, V0 domain endosome phagocytic vesicle membrane membrane apical plasma membrane vacuolar proton-transporting V-type ATPase complex endosome membrane extracellular exosome lysosomal membrane early endosome plasma membrane proton-transporting V-type ATPase complex Biological process insulin receptor signaling pathway transferrin transport ion transport ion transmembrane transport regulation of macroautophagy phagosome acidification vacuolar transport vacuolar acidification transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 245972 242341 Ensembl ENSG00000147614 ENSMUSG00000028238 UniProt Q8N8Y2 Q80SY3 RefSeq (mRNA) NM_152565 NM_175406 RefSeq (protein) NP_689778 NP_780615 Location (UCSC) Chr 8: 85.99 – 86.15 Mb Chr 4: 19.88 – 19.92 Mb PubMed search [3] [4]
Wikidata
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ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 is a protein in humans that is encoded by the ATP6V0D2 gene. [5] It is part of proton pumps in the plasma membranes of osteoclasts and aids with extracellular acidification in bone resorption. [6]

References

1. GRCh38: Ensembl release 89: ENSG00000147614 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028238 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2". Retrieved 2012-11-12.
6. Wu H, Xu G, Li YP (May 2009). "Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption". Journal of Bone and Mineral Research. 24 (5): 871–85. doi:10.1359/jbmr.081239. PMC 2672205. PMID 19113919.

External links

• Human ATP6V0D2 genome location and ATP6V0D2 gene details page in the UCSC Genome Browser.

Further reading