en AMY1C

AMY1C
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1C8Q, 1JXJ, 1JXK, 1MFU, 1MFV, 1NM9, 1Q4N, 1SMD, 1XV8, 1Z32, 3BLK, 3BLP, 3DHP
Identifiers
Aliases	AMY1C, AMY1, amylase, alpha 1C (salivary), amylase alpha 1C (salivary), amylase alpha 1C
External IDs	OMIM: 104702; HomoloGene: 133998; GeneCards: AMY1C; OMA:AMY1C - orthologs
EC number	3.2.1.1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	103,758,726 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; testicle; ; olfactory zone of nasal mucosa; ; gonad; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of pancreas; ; right lung; ; upper lobe of left lung; ; left testis;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; alpha-amylase activity; hydrolase activity; catalytic activity; metal ion binding; hydrolase activity, acting on glycosyl bonds; cation binding;
Cellular component	extracellular region; extracellular exosome; extracellular space;
Biological process	digestion; metabolism; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	278
	n/a
	ENSG00000187733
	n/a
	P04745
	n/a
	NM_001008219; NM_001346780
	n/a
	NP_001008220; NP_001333709; NP_001008222; NP_004029; NP_001008219
	n/a
	Wikidata
View/Edit Human

The human AMY1C gene encodes the protein Amylase, alpha 1C (salivary). ^[3]

Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either the salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland.^[4] See also Amylase § Evolution.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187733 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Amylase, alpha 1C (salivary)". Retrieved 2013-02-14.
^ [provided by RefSeq, Jul 2008]. ##RefSeq-Attributes-START## Transcript_exon_combination_evidence :: AK313275.1 [ECO:0000332] ##RefSeq-Attributes-END##

Overview of all the structural information available in the PDB for UniProt: P04745 (Human Alpha-amylase 1) at the PDBe-KB.