ACER2

ACER2
Identifiers
Aliases	ACER2, ALKCDase, ASAH3L, alkalina ceramidasa, ALKCDase2, alkaline ceramidase 2
External IDs	OMIM: 613492; MGI: 1920932; HomoloGene: 14986; GeneCards: ACER2; OMA:ACER2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p22.1 Start 19,409,009 bp[1] End 19,452,505 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C4 Start 86,792,633 bp[2] End 86,853,059 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in urinary bladder gonad placenta subcutaneous adipose tissue stomach testicle body of stomach duodenum body of pancreas islet of Langerhans Top expressed in transitional epithelium of urinary bladder right lung right lung lobe left lung embryo tail of embryo genital tubercle gastrula atrium left lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function dihydroceramidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity N-acylsphingosine amidohydrolase activity ceramidase activity metal ion binding Cellular component integral component of membrane integral component of Golgi membrane Golgi apparatus membrane Golgi membrane Biological process positive regulation of cell death response to retinoic acid ceramide metabolic process lipid metabolism sphingosine biosynthetic process sphingolipid biosynthetic process negative regulation of cell-matrix adhesion positive regulation of cell population proliferation activation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cell adhesion mediated by integrin cellular response to DNA damage stimulus regulation of autophagy DNA damage response, signal transduction by p53 class mediator regulation of apoptotic process ceramide catabolic process sphingolipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 340485 230379 Ensembl ENSG00000177076 ENSMUSG00000038007 UniProt Q5QJU3 Q8VD53 RefSeq (mRNA) NM_001010887 NM_001290541 NM_001290543 NM_139306 NM_028605 RefSeq (protein) NP_001010887 NP_001277470 NP_001277472 NP_647467 Location (UCSC) Chr 9: 19.41 – 19.45 Mb Chr 4: 86.79 – 86.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.[5]

Function

The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000177076 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038007 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mao C, Obeid LM (September 2008). "Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate". Biochim. Biophys. Acta. 1781 (9): 424–34. doi:10.1016/j.bbalip.2008.06.002. PMC 2614331. PMID 18619555.
6. Sun W, Hu W, Xu R, Jin J, Szulc ZM, Zhang G, Galadari SH, Obeid LM, Mao C (February 2009). "Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion". FASEB J. 23 (2): 656–66. doi:10.1096/fj.08-115634. PMC 2630785. PMID 18945876.

External links

• Human ACER2 genome location and ACER2 gene details page in the UCSC Genome Browser.

Further reading

• Xu R, Jin J, Hu W, et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P". FASEB J. 20 (11): 1813–25. doi:10.1096/fj.05-5689com. PMID 16940153. S2CID 20973940.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.