6-carboxytetrahydropterin synthase

6-carboxytetrahydropterin synthase
6-Carboxy-5,6,7,8-tetrahydropterin synthase hexamer, E.Coli
Identifiers
EC no.	4.1.2.50
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

6-carboxytetrahydropterin synthase (EC 4.1.2.50, CPH4 synthase, queD (gene), ToyB , ykvK (gene)) is an enzyme with systematic name 7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming).[1][2] This enzyme catalyses the following reversible chemical reaction.

7,8-dihydroneopterin 3′-triphosphate + H₂O ⇌ 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + triphosphate

This enzyme binds Zn^2+. It is isolated from the bacteria Bacillus subtilis and Escherichia coli. The stimulation is part of the biosynthesis pathway of queuosine. The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin.[2]

References

1. Cicmil N, Shi L (February 2008). "Crystallization and preliminary X-ray characterization of queD from Bacillus subtilis, an enzyme involved in queuosine biosynthesis". Acta Crystallographica Section F. 64 (2): 119–22. doi:10.1107/s1744309108000924. PMC 2374184. PMID 18259064.
2. McCarty RM, Somogyi A, Bandarian V (March 2009). "Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase". Biochemistry. 48 (11): 2301–3. doi:10.1021/bi9001437. PMC 3227869. PMID 19231875.

External links

• Media related to 6-carboxytetrahydropterin synthase at Wikimedia Commons
• 6-carboxytetrahydropterin+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)