American college football season
The 2022 Southern Illinois Salukis football team represented Southern Illinois University Carbondale as a member of the Missouri Valley Football Conference (MVFC) during the 2022 NCAA Division I FCS football season. Led by seventh-year head coach Nick Hill, the Salukis played their home games at Saluki Stadium in Carbondale, Illinois.
Schedule
Date | Time | Opponent | Rank | Site | TV | Result | Attendance |
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| 6:00 p.m. | at No. 14 Incarnate Word* | No. 9 | | ESPN+ | L 29–64 | 2,656 |
September 10 | 6:00 p.m. | Southeast Missouri State* | No. 17 | | ESPN3 | L 31–34 | 8,662 |
September 17 | 11:00 a.m. | at Northwestern* | | | BTN | W 31–24 | 23,146 |
September 24 | 2:00 pm | No. 19 North Dakota | No. 24 | - Saluki Stadium
- Carbondale, IL
| ESPN+ | W 34–17 | 8,053 |
October 1 | 6:30 p.m. | at Illinois State | No. 19 | | Marquee | W 19–14 | 11,127 |
October 8 | 2:00 p.m. | at No. 20 Missouri State | No. 17 | | ESPN+ | W 38–21 | 7,061 |
October 15 | 2:00 p.m. | Western Illinois | No. 16 | - Saluki Stadium
- Carbondale, IL
| ESPN+ | W 30–7 | 10,118 |
October 22 | 2:00 p.m. | at South Dakota | No. 14 | | ESPN+ | L 24–27 | 7,599 |
October 29 | 2:00 pm | Northern Iowa | No. 20 | - Saluki Stadium
- Carbondale, IL
| ESPN3 | L 36–37 | 6,155 |
November 12 | 1:00 p.m. | No. 4 North Dakota State | | - Saluki Stadium
- Carbondale, IL
| ESPN+ | L 18–21 | 4,575 |
November 19 | 11:00 a.m. | at Youngstown State | | | ESPN3 or ESPN+ | L 21–28 | |
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References
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National championship seasons in bold |