The 2022 Grand Prix of Portland was the sixteenth And penultimate round of the 2022 IndyCar season. The race was held on September 4, 2022, in Portland, Oregon at the Portland International Raceway. Scott McLaughlin qualified on pole. To prevent a first lap first corner pileup the drivers agreed to get the green flag further back on the front straight than previous years. This early start was successful in preventing a first lap pileup, and the race went 97 laps without a yellow. McLaughlin led 104 of 110 laps and won the race from pole. Will Power and Scott Dixon rounded out the podium.
^Josef Newgarden received a six-place grid penalty due to an unapproved engine change.[4]
^Dalton Kellett received a six-place grid penalty due to an unapproved engine change. However, qualifying in last place meant this penalty had no impact.[4]