The draw took place in Šibenik during the women's LEN European Junior Water Polo Championship.[2] The top four ranked sides will advance from both groups.
The winners in the third round will continue in the preliminary round. The losers in the third round will be transferred in the Euro Cup quarter-finals.[5]
The draw for the 2021–22 LEN Champions League preliminary round took place in Ostia, Italy.[6] The upcoming season is planned with the usual pre-pandemic round-robin format with 14 rounds contested on a home-and-away basis. The top three teams in group A and the top four teams in group B will advance to the Final 8. Also, Novi Beograd will participate in the Final 8 as the host of tournament. The matchdays will be from 26 October 2021 to 15 June 2022.[7]