The 2021–22 season was the 55th season of Denizlispor in existence and the club's first season back in the TFF First League, after being relegated from the Turkish first division Süper Lig previous season, finishing in last place. In addition to the domestic league, Denizlispor participated in this season's edition of the Turkish Cup. The season covers the period from July 2021 to 30 June 2022.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
^"Hoş geldin Muğdat Çelik" (in Turkish). denizlispor.org.tr. 23 August 2021. Archived from the original on 3 September 2021. Retrieved 3 September 2021.
^"Hoş geldin Erdal Akdarı" (in Turkish). denizlispor.org.tr. 24 August 2021. Archived from the original on 3 September 2021. Retrieved 3 September 2021.
^"Hoş geldin Brahim Darri" (in Turkish). denizlispor.org.tr. 25 August 2021. Archived from the original on 3 September 2021. Retrieved 3 September 2021.
^"Hoş geldin İlhan Depe" (in Turkish). denizlispor.org.tr. 1 September 2021. Archived from the original on 3 September 2021. Retrieved 3 September 2021.