The 2020–21 season was the 110th season in the existence of Brescia Calcio and the club's first season back in the second division of Italian football. In addition to the domestic league, Brescia participated in this season's edition of the Coppa Italia.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.