Note: A driver designated with a (R) next to their name indicates that they are contenders for the 2012 Rookie of the Year award.
Team changes
The Kevin Harvick, Inc.-Richard Childress Racing Merger and Related Spinoff
Richard Childress Racing, per agreement in the Kevin Harvick, Inc. merger agreement, acquired the 2011 Owners Champion No. 2 truck as part of the Harvick-Childress merger that also included the No. 2 and No. 33 Nationwide teams. The No. 8 and No. 33 trucks were spun off in a separate deal.
Harvick spun off the No. 8 and No. 33 Truck teams, which Eddie Sharp Racing, acquired. The teams in the spinoff join the present No. 6 truck driven by Justin Lofton to form a three-truck team, which resulted in a September 2011 decision to switch manufacturers from Toyota to Chevrolet immediately, with support from Childress. The spinoff also included development driver Cale Gale, who drove the No. 33 Rheem Chevrolet.
Germain Racing had shut down the No. 9 and No. 30 trucks with employees asked to look for other employment, as the team's Sprint Cup team changed to Ford from Toyota.
Driver changes
Changed teams
Neither of the Kevin Harvick, Inc. drivers were retained by Eddie Sharp Racing after the spinoff. Ron Hornaday Jr. joined Joe Denette Motorsports and drive their No. 9 Chevrolet. He was reunited with KHI crew chief Jeff Hensley. Hornaday was not an exempt driver through the points standings during the first five races, but had an exemption through his status as a former Series Champion. (Series champions have an exemption available in certain circumstances.)
After Germain Racing shut down its Truck Series operations, Todd Bodine moves to Red Horse Racing to driving the No. 11 truck that was the No. 7 that Miguel Paludo drove. However, Bodine tweeted that he needed sponsorship to run the season.
After a disappointing 2011, David Starr took the number 81 with him to the newly formed Arrington Racing formed by engine builder Joey Arrington.
The Rookie of the Year standout would be Ty Dillon, the younger brother of 2011 Champion Austin Dillon. Ty scored a win at Atlanta and was in contention for the championship until a late crash at Homestead knocked him to 4th in the points but easily won him the RoTY title. Former Kevin Harvick, Inc. development driver Cale Gale was runner-up to Dillon, taking a pole at Bristol and a win at Homestead. Ross Chastain finished 3rd in the rookie battle, while John Wes Townley, despite missing Daytona, had two top-10s. Contenders Jeb Burton, Dakoda Armstrong, and Daytona winner John King saw their runs for RoTY aborted due to sponsorship issues. K&N Pro Series East Champion Max Gresham struggled with Joe Denette Motorsports and departed the team early on. Duke University graduate Paulie Harraka struggled most of the season with Wauters Motorsport and left before Atlanta.
Returned to the series
Tim George Jr. returned to the Truck Series for the first time since 2009. He ran 12 races driving Richard Childress Racing's No. 2 truck inherited from Kevin Harvick, Inc.
David Reutimann returns to the series for 4 races with RBR Enterprises.
Ward Burton returned to NASCAR for the first time after a five-year absence, driving the season-opening Daytona race for Hillman Racing. His son Jeb would drive the following 4 races before a lack of sponsorship ended his run.
Exited the series
Truck Series champion and former Rookie of the Year Austin Dillon moved up to the NASCAR Nationwide Series full-time with crew chief Danny Stockman.
The Las Vegas race, as a result of issues resulting from the 2011 race weekend, was moved back to late September as a stand-alone race. Originally, the Las Vegas race was set for 13 October at 12 noon PDT as part of the IndyCar weekend, but Indy Racing League LLC faces issues from the 2011 IZOD IndyCar World Championship which the 2011 Truck race was the Saturday feature of the race meet, but that meet was removed as a result of legal issues following the death of Dan Wheldon on Lap 11 of the IZOD IndyCar Series feature.
Speedway Motorsports also removed races from New Hampshire Motor Speedway, while keeping the second Kentucky truck date and having the NASCAR Nationwide Series replace INDYCAR on the fall weekend. Darlington was also removed from the schedule, both Nashville races, and Lucas Oil Motorsports Park. Chicagoland also moved to July. Kansas moved from June to April, along with the Cup series as their spring date was also moved to April to give more time for Kansas's new configuration project. Rockingham Speedway was added to the truck series schedule marking the first time since 2004 NASCAR has had a race at the track. The total of races on the schedule was also reduced from 25 to 22. Iowa Speedway also got a second date that was held in September.