The 2012–13 Real Valladolid season was the club's first season in La Liga since its relegation at the end of the 2009–10 season. The club's manager in the previous season, Miroslav Đukić, continued with the team.
In the morning training of 5 January 2013, Víctor Pérez broke the fibula in his right leg fortuitously, and at the evening he underwent surgery in the Hospital Sagrado Corazón by Dr. Rafael Ramos, chief of Real Valladolid's medical service. The estimated time for recovery of his injury is about four months approximately, so he would miss the remainder of the season.
^Officially called "Centenary Trophy Luarca CF" Because the local team, Luarca CF, was founded in 1912.
^ abcHe returned to the club so as to play in the youth squad.
^Start delayed until 20:55 (19:55 local time) because of the delay of Beira-Mar presentation events in its stadium. The match was scheduled at 19:30 local time.
^The team that wins this variable will be qualified ahead of another with the same points but lost on goal average. If the goal average is drawn between two or more teams and, at the end of the season these teams have the same points, the overall Liga BBVA's goal average prevails over this goal average.