The 2000 Cork Senior Football Championship was the 112th staging of the Cork Senior Football Championship since its establishment by the Cork County Board in 1887. The draw for the opening fixtures took place on 12 December 1999. The championship began on 16 April 2000 and ended on 1 October 2000.
On 1 October 2000, Nemo Rangers won the championship following a 1-14 to 0-07 defeat of Carbery in the final. This was their 11th championship title overall and their first title since 1993.
Paul Holland from the Clyda Rovers club was the championship's top scorer with 2-40.