The 2000–01 season was Olympiacos's 42nd consecutive season in the Alpha Ethniki and their 75th year in existence. The club were played their 4th consecutive season in the UEFA Champions League. In the beginning of the summertime Olympiacos named Greek Takis Lemonis coach.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Source: Galanis Sports Data Rules for classification: 1) Points; 2) Head-to-head points; 3) Head-to-head goal difference; 4) Goal difference; 5) Goals scored; 6) Goals against; 7) Play-offs (neutral ground); 8) Draw. (Note: Criterion 7 is only used if needed to decide champion, teams for relegation or teams for UEFA competitions). (C) Champions Notes: