(+)-Menthofuran synthase

(+)-Menthofuran synthase
Identifiers
EC no.	1.14.13.104
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

(+)-Menthofuran synthase (EC 1.14.13.104, menthofuran synthase, (+)-pulegone 9-hydroxylase, (+)-MFS, cytochrome P450 menthofuran synthase) is an enzyme with systematic name (+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction

(+)-pulegone + NADPH + H^+ + O₂ ${\displaystyle \rightleftharpoons }$ (+)-menthofuran + NADP+ + H₂O

Menthofuran synthase is a heme-thiolate protein (P-450).

References

1. Bertea CM, Schalk M, Karp F, Maffei M, Croteau R (June 2001). "Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene". Archives of Biochemistry and Biophysics. 390 (2): 279–86. doi:10.1006/abbi.2001.2378. PMID 11396930.
2. Mahmoud SS, Croteau RB (November 2003). "Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase". Proceedings of the National Academy of Sciences of the United States of America. 100 (24): 14481–6. Bibcode:2003PNAS..10014481M. doi:10.1073/pnas.2436325100. PMC 283617. PMID 14623962.

External links

• (+)-menthofuran+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)